Background Scarring is a distressing outcome of acne, as it causes cosmetic and psychological problems to the patients. Unfortunately no single treatment is satisfactory; instead, employing multiple modalities may have better outcome. Autologous adipose tissue‐derived adult stem cells (AT‐ASCs) and their secretory factors can stimulate collagen synthesis; angiogenesis and migration of fibroblasts thus regenerate damaged tissues. Also, conventional treatments for acne scarring, such as lasers and topical regimens, induce new collagen synthesis via activation of dermal fibroblasts or growth factors. The aim of the study was to verify the effectiveness of AT‐ASCs for the treatment of acne scarring vs. the fractional carbon dioxide laser (FxCR). Subjects and methods Split face comparative study included 10 adult patients with post‐acne scars on both sides of the face. One side received AT‐ASCs single injection while the other received three sessions of FxCR. Scars were then assessed using the global scoring system Goodman and Baron, scar area percent using NIH ImageJ software and functional assessment by measuring the transepidermal water loss (TEWL) and skin hydration. Both sides were followed for three months. Results A significant improvement in the degree of scar severity, scar area percent, skin hydration, and TEWL after 3 months of treatment on both sides of the face with insignificant differences between both treatment modalities, provided that AT‐ASCs treatment was employed once vs. three sessions of FxCR. Conclusion One injection of AT‐ASCs is as effective as three sessions of FxCR in the treatment of atrophic acne scars.

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Background Administration of narrow-band ultraviolet B (NB-UVB) is a routine treatment modality for psoriasis, but its effect on human b-defensin 2 (HBD2) level has not been well studied.Aim of the study The aim of the study was to assess immunohistochemically the expression of HBD2 in patients before treatment and compare the results with controls and also assess immunohistochemically the expression of HBD2 in psoriatic lesions before and after NB-UVB phototherapy treatment, thereby assessing the effect of NB-UVB phototherapy treatment on HBD2 expression. Patients and methodsThis study included 30 patients with psoriasis and 30 age-matched and sex-matched controls. HBD2 expression was detected by immunohistochemical analysis in patients before and after NB-UVB treatment. It was also detected in control specimens, which were obtained from excess skin that was removed as a routine during procedures such as abdominoplasty and partial thickness skin grafting in the plastic surgery department.A 50-year-old male patient with a mild Psoriasis Area and Severity Index score of 6.4 before treatment, which reduced to 1.6 after treatment.NB-UVB on the expression of HBD2 Aly et al. 45