Background:The concentration of interleukin-27 (IL-27) in pleural effusions was found to be increased in tuberculous pleurisy and several studies have investigated the diagnostic value of IL-27 for tuberculous pleural effusions (TPEs), but the results varied a lot. We conducted the present study to comprehensively evaluate the diagnostic value of IL-27 for TPE.Methods:Primary diagnostic test studies of IL-27 for TPE was searched and identified from databases. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ration, diagnostic odds ratio, and receiver operating characteristic curves (SROCs) were computed or pooled to summarize the overall test performance.Results:Nine studies with a total number of 1226 patients were identified in our research. The main pooled estimates were as follows: sensitivity 0.92 [95% confidence interval (CI), 0.90–0.95], specificity 0.90 (95% CI, 088–0.92), and area under the SROC 0.97. No evidence of publication bias was detected.Conclusion:Our research suggested the good diagnostic value of IL-27 for TPE and it could be used as a diagnostic biomarker.
Background:The diagnosis of tuberculous pleurisy is difficult and traditional methods are not always helpful. Many studies have focused on the tumor necrosis factor-alpha (TNF-α) assay in pleural effusion for the diagnosis of tuberculous pleurisy, but the results remain controversial. This meta-analysis was conducted to determine the overall diagnostic accuracy of TNF-α.Methods:Relevant studies were searched from PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wangfang, and Weipu. We pooled the published results and computed the accuracy measures, including sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). Receiver operating characteristic curves (SROC) and the area under the curve (AUC) were used to summarize the overall test performance.Results:Twelve studies with 1022 patients met the inclusion criteria. The pooled sensitivity and specificity were 0.85 (95%CI, 0.81–0.89) and 0.80 (95% CI, 0.77–0.83) respectively. The area under the SROC curve was 0.89.Conclusions:The results of meta-analysis suggested that the TNF-α assay plays a vital role in the diagnosis of tuberculous pleurisy, whereas other test results or clinical findings should be interpreted together with the TNF-α assay to improve the overall diagnostic accuracy.
Rationale:Primary clear cell carcinoma of the lung is a rare condition, and presentation as an endotracheal lesion is even more unusual. In this report, we present a patient with clear cell carcinoma occurring in the trachea, which obstructed the tracheal lumen and lead to the respiratory distress.Patient concerns:A 60-year old female patient was admitted due to a 6-month history of dyspnea with worsening symptoms for 1 month. Chest CT scan revealed a smooth nodular shadow with homogeneous density on the wall of upper trachea.Diagnosis:Bronchoscopy therapy and surgical removal of the tumor were performed. The histopathological diagnosis revealed clear cell carcinoma.Intervention:Surgical removal of the clear cell carcinoma was performed.Outcomes:The patient recovered well after the surgery and is now being followed-up after hospital discharge.Lessons:Bronchoscopy is an essential tool for diagnosis of tracheal clear cell carcinoma. Surgical removal should be performed if possible.
The ever-increasing water stress and availability of fresh drinking water are becoming a major challenge in rural and urban communities. The current high-end and large-scale technologies are becoming way more expensive and not friendly to the environment. In this regard, solar still is becoming a prominent and promising future technology due to its environment-friendly nature, less maintenance and operational costs, and simple design. The technological challenge regarding solar still is its low distillate yield. In this study, an attempt has been made to investigate the effect of tin oxide (SnO2) on the absorption surface of solar still towards improvement in sunlight absorption, which would lead to high distillate production rates. Various concentrations of SnO2, i.e., 0.5wt%, 1 wt%, 3 wt%, 5 wt%, 7 wt%, 10 wt%, 15 wt%, and 20 wt%, have been mixed in black and applied on the absorber plate to further optimize the suitable concentration. The experiments have been performed in both indoor (simulated) and outdoor conditions. An increase in surface temperature of absorber plate has been observed with increasing concentration of SnO2 under both the indoor and outdoor conditions, which is due to high solar spectrum absorption properties of SnO2 in the ultraviolet (UV) and near to far-infrared (IR) regions. The highest surface temperature of 101.61°C has been observed for specimens containing 15 wt% SnO2 in black paint under indoor conditions at 1000W/m2 irradiation levels, which is 53.67% higher compared to bare aluminum plate and 16.91% higher compared to only black paint coated aluminum plate. On the other hand, the maximum temperature of 74.96°C has been recorded for the identical specimens containing 15 wt% SnO2 under uncontrolled outdoor conditions. The recorded temperature is 47.96% higher than the bare aluminum plate and 14.88% higher than the black paint-coated aluminum plate. The difference of maximum temperatures under indoor and outdoor conditions is due to uncontrolled outdoor conditions and convective losses.
The optimal colonoscopic surveillance interval in the Chinese population is unclear. The present study aimed to assess the optimal colonoscopic surveillance interval after normal baseline screening colonoscopy to avoid overuse or underuse of colonoscopy. This retrospective study included individuals with normal baseline colonoscopy who had undergone at least 2 follow-up colonoscopy examinations at the Digestive Endoscopy Center of our hospital between 2000 and 2013. The risk factors for adenoma and the optimal colonoscopic surveillance interval were assessed. A total of 1,005 individuals (419 men; mean age, 49.34 ± 13.29 years) were included in the study. Of these, 169 individuals had adenomas at colonoscopic surveillance (mean, 1.32 ± 0.79 procedures). The mean adenoma diameter was 0.54 ± 0.38 cm, and the mean number of adenomas was 1.76 ± 1.29. The mean adenoma surveillance interval was 4.76 ± 2.89 years. The risk factors for adenoma identification were age more than 50 years and male gender. The optimal colonoscopic surveillance interval was 4.76 years according to an adenoma detection rate of 5%. The optimal colonoscopic surveillance interval is around 5 years for individuals with normal baseline colonoscopy. Age more than 50 years and male gender are risk factors for adenoma identification.
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