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This review summarizes and systematizes the literature on the anti-HIV activity of plant coumarins with emphasis on isolation and the mechanism of their antiviral action. This review summarizes the information on the anti-HIV properties of simple coumarins as well as annulated furano- and pyranocoumarins and shows that coumarins of plant origin can act by several mechanisms: inhibition of HIV reverse transcriptase and integrase, inhibition of cellular factors that regulate HIV-1 replication, and transmission of viral particles from infected macrophages to healthy ones. It is important to note that some pyranocoumarins are able to act through several mechanisms or bind to several sites, which ensures the resistance of these compounds to HIV mutations. Here we review the last two decades of research on the anti-HIV activity of naturally occurring coumarins.

A green protocol has been developed for the synthesis of simple coumarins and linear pyrano[2,3-f] and [3,2-f]indoles by the reaction of phenol derivatives with β-ketoesters under ball milling at ambient...

Phenol derivatives are widespread as important building blocks in various pharmaceuticals, agrochemicals and materials. Modern economy requires development of “green” methodologies that improve the efficiency of their use and reduction of waste. One such method is the C−H/C−H cross‐coupling, also known as the cross‐dehydrogenative coupling reaction. In this review article, we have summarised the C−H/C−H cross‐coupling reactions of phenols with five‐ and six‐membered heterocyclic compounds, systemised methods of activation of phenol or coupling partner. We discuss these advances with the goal of motivating increased interest to develop novel methodologies in this field of organic chemistry.