Background and aims Long COVID is the collective term to denote persistence of symptoms in those who have recovered from SARS-CoV-2 infection. Methods WE searched the pubmed and scopus databases for original articles and reviews. Based on the search result, in this review article we are analyzing various aspects of Long COVID. Results Fatigue, cough, chest tightness, breathlessness, palpitations, myalgia and difficulty to focus are symptoms reported in long COVID. It could be related to organ damage, post viral syndrome, post-critical care syndrome and others. Clinical evaluation should focus on identifying the pathophysiology, followed by appropriate remedial measures. In people with symptoms suggestive of long COVID but without known history of previous SARS-CoV-2 infection, serology may help confirm the diagnosis. Conclusions This review will helps the clinicians to manage various aspects of Long COVID.

Background: COVID-19 vaccines have been rolled out recently in several parts of the world. Although the protective efficacy is frequently discussed, little is known about the real-world post-vaccination experience outside of clinical trial conditions. Knowledge about what to expect after vaccination will help educate the public, dispel misinformation and reduce vaccine hesitancy. Aim: 1. To assess the immediate response to the first dose of COVID-19 vaccine. 2. To study the spectrum of post-vaccination symptom profile for individual vaccines. Methods: A cross-sectional online survey was done which included questions pertaining to the immediate post vaccination experience in India. Results: A total of 5396 people responded to the survey over a one-week period from 29 January to 4 February. Overall, 65.9 % of respondents reported at least one post-vaccination symptom. Tiredness (45%), myalgia (44%), fever (34%), headache (28%), local pain at injection site (27%), joint pain (12%), nausea (8%) and diarrhea (3%) were the most prevalent symptoms. The chance of having symptoms decreased with advancing age. The frequency of symptoms was 81% (3rd decade or 20-29 years), 80% (4th decade or 30-39 years), 68% (5th decade), 58% (6th decade), 45% (7th decade), 34% (8th decade) and 7% (9th decade, 80-90 years). Post-vaccination symptoms were more likely to be reported by women (74.7%) compared to men (58.6%) (p < 0.001). Among those who reported symptoms, 79% noticed them within the first 12 hours. 472 out of 5396 (8.7%) reported past history of COVID-19. Their symptom profile was not different to those who did not have a past history. Conclusions: Two-thirds of healthcare professionals who completed the survey reported mild and short-lived post-vaccination symptoms. Tiredness, myalgia and fever were most commonly reported. These symptoms were consistent with an immune response commonly associated with vaccines, and correlated with the findings from previously published phase 2/3 trials. In 90% cases, the symptoms were either milder than expected or meeting the expectation of the vaccine recipient. No serious events were reported. Symptoms were more common among younger individuals. There was no difference in symptoms among those who had a past history of COVID-19.

The widespread use of computed tomography (CT) scanning technology frequently leads to the incidental discovery of thickened bowel wall. The clinical significance of such a CT scan finding is largely under-investigated. The purpose of our study was to determine the incidence of significant clinical pathology and, particularly, neoplasia in patients with abnormally thickened bowel on CT scan examination. This is a single institution retrospective analysis of patients that underwent CT scanning of their abdomen. The radiological picture was correlated with colonoscopic findings. A total of 40 consecutive patients with thickened bowel on CT scan that also underwent colonoscopy were identified and their records were reviewed. Thirty-five patients had no history of previous gastrointestinal disorder and form our study group. The median age of the patients was 69 years (range, 24–97 years). There were 26 female and 9 male patients. The incidental CT finding of bowel wall thickening was the only reason for the colonoscopy in 14 (35%) out of the 40 patients. Eight (23%) patients with thick bowel had colonic neoplasia based on pathology. Five (14%) patients had invasive adenocarcinoma of the colon. Four (11%) of the 5 patients with colon adenocarcinoma did not have any associated gastrointestinal symptoms or signs. One (3%) patient had lymphoma of the colon and two (6%) had benign polyps. Colonoscopy was unremarkable in 10 (28%) patients. The incidental finding of colonic thickening on CT imaging could be associated with underlying colonic malignancy and, more importantly, represent the initial disease presentation. Therefore, we propose that these patients should undergo colonoscopy.

Background: Data on the occurrence of colorectal polyps in the Indian subcontinent is scant. To study this, we conducted a retrospective analysis on 1604 consecutive patients who underwent colonoscopy. Methods: The objective was to study the prevalence of colorectal polyps and adenomas among various age groups in the Indian subcontinent and to determine a cutoff age for screening for colon polyps. The parameters we considered were age, gender, indications and diagnosis. All polyps were removed colonoscopically by polypectomy, and the specimen was sent for histopathological examination. Results: A total of 1604 colonoscopies were performed. The mean age was 47 years, 67.21% were above 40 years of age, and 32.79% were below 40 years. Polyps were detected in 11% of all patients and in 14.7% of patients over age 40. Out of all polyps found, 41.8% were adenomatous polyps, 49.5% were hyperplasic polyps and 12.7% were others like inflammatory and hamartomatous polyps. Among the adenomas, 45.8 % were found to be advanced adenomas. Prevalence of adenomatous polyps increased significantly above the age of 40 (P <0.001). Conclusion: One out of six people in South India over age 40 had a polyp. The risk of occurrence of colorectal adenoma increased fivefold after age 40.