The Cover Feature shows comparative kinetic studies of nitrosyl ruthenium complexes such as cis‐[Ru(NO)(bpy)2L]3+ (L=4‐pic, py, isn, and 4‐acpy) used as a platform for understanding the effect of the interaction between biphthalate, phosphate, and imidazole buffer solutions and the ruthenium complex to enable the conversion of nitrosyl to nitrite at pH=6.5. The buffer can dramatically improve the rate of the reaction to make it around three times faster in the order: biphthalate
Nitrogen oxide derivative ruthenium compounds can deliver nitric oxide (NO) by chemical, electrochemical, or photochemical processes. Among these compounds, nitrosyl ruthenium complexes have been one of the most studied species. The σand π-character of the co-ligand L in [RuL 5 (NO)] n + exerts a unique and determining effect on the structure of the complex and the NO delivery mode. We have found inconsistencies in this assertion. How the buffer medium influences the hydrolysis rate constant of nitrosyl ruthenium complexes such as cis-[Ru(NO)(bpy) 2 L] 3 + + (L = 4-pic; py; isn and 4-acpy) has been evaluated in biphthalate, phosphate, and imidazole buffer solutions. For the studied ruthenium complexes, hydrolysis depended on the π-acceptor character of ligand "L", with k obs increasing in the following order: 4-pic < py < isn < 4-acpy. For nitrite conversion, the relative efficiency of the buffers increased in the order: biphthalate < phosphate < imidazole for all the studied nitrosyl ruthenium complexes. On the basis of these findings, we hypothesized that the second-coordination sphere interacts with the ruthenium complexes. By conducting theoretical modeling studies, we have elucidated the potential contribution of this interaction to nitrosyl/nitrite interconversion.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.