The intrinsic value of biodiversity extends beyond species diversity, genetic heritage, ecosystem variability and ecological services, such as climate regulation, water quality, nutrient cycling and the provision of reproductive habitats it is also an inexhaustible source of molecules and products beneficial to human well-being. To uncover the chemistry of Brazilian natural products, the Nuclei of Bioassays, Ecophysiology and Biosynthesis of Natural Products Database (NuBBEDB) was created as the first natural product library from Brazilian biodiversity. Since its launch in 2013, the NuBBEDB has proven to be an important resource for new drug design and dereplication studies. Consequently, continuous efforts have been made to expand its contents and include a greater diversity of natural sources to establish it as a comprehensive compendium of available biogeochemical information about Brazilian biodiversity. The content in the NuBBEDB is freely accessible online (https://nubbe.iq.unesp.br/portal/nubbedb.html) and provides validated multidisciplinary information, chemical descriptors, species sources, geographic locations, spectroscopic data (NMR) and pharmacological properties. Herein, we report the latest advancements concerning the interface, content and functionality of the NuBBEDB. We also present a preliminary study on the current profile of the compounds present in Brazilian territory.

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Anxiety disorders are the most prevalent psychiatric disorders and a leading cause of disability. While there continues to be expansive research in posttraumatic stress disorder (PTSD), depression and schizophrenia, there is a relative dearth of novel medications under investigation for anxiety disorders. This review's first aim is to summarize current pharmacological treatments (both approved and off-label) for panic disorder (PD), generalized anxiety disorder (GAD), social anxiety disorder (SAD), and specific phobias (SP), including selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), azapirones (e.g., buspirone), mixed antidepressants (e.g., mirtazapine), antipsychotics, antihistamines (e.g., hydroxyzine), alpha- and beta-adrenergic medications (e.g., propranolol, clonidine), and GABAergic medications (benzodiazepines, pregabalin, and gabapentin). Posttraumatic stress disorder and obsessive-compulsive disorder are excluded from this review. Second, we will review novel pharmacotherapeutic agents under investigation for the treatment of anxiety disorders in adults. The pathways and neurotransmitters reviewed include serotonergic agents, glutamate modulators, GABAergic medications, neuropeptides, neurosteroids, alpha- and beta-adrenergic agents, cannabinoids, and natural remedies. The outcome of the review reveals a lack of randomized double-blind placebo- controlled trials for anxiety disorders and few studies comparing novel treatments to existing anxiolytic agents. Although there are some recent randomized controlled trials for novel agents including neuropeptides, glutamatergic agents (such as ketamine and d-cycloserine), and cannabinoids (including cannabidiol) primarily in GAD or SAD, these trials have largely been negative, with only some promise for kava and PH94B (an inhaled neurosteroid). Overall, the progression of current and future psychopharmacology research in anxiety disorders suggests that there needs to be further expansion in research of these novel pathways and larger-scale studies of promising agents with positive results from smaller trials.

SUMMARY By directional training, young domestic chickens have been shown to use a magnetic compass; the same method has now been used to analyse the functional characteristics and the physical principles underlying the chickens' magnetic compass. Tests in magnetic fields with different intensities revealed a functional window around the intensity of the local geomagnetic field, with this window extending further towards lower than higher intensities. Testing chickens under monochromatic 465 nm blue and 645 nm red light suggested a wavelength dependence, with orientation possible under blue but not under red light. Exposing chickens to an oscillating field of 1.566 MHz led to disorientation, identifying an underlying radical pair mechanism. Local anesthesia of the upper beak, where iron-rich structures have been described as potential magnetoreceptors, did not affect the performance, suggesting that these receptors are not involved in compass orientation. These findings show obvious parallels to the magnetic compass described for European robins,indicating that chickens and small passerines use the same type of magnetic compass mechanism. This suggests that the avian magnetic compass may have evolved in the common ancestor of all present-day birds to facilitate orientation within the home range.

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RESUMOIntrodução: A prática regular de atividade física (PRAF) é fundamental em qualquer idade e tem sido considerada um meio de preservar e melhorar a saúde e a qualidade de vida do ser humano. A inatividade física é um importante fator de risco de doenças crônicas não transmissíveis, como diabetes e hipertensão arterial. Objetivo: Determinar a prevalência e os fatores associados à PRAF em adolescentes, adultos e idosos. Métodos: Estudo transversal, de base populacional, realizado no norte do estado de Minas Gerais, Brasil. Foi adotada amostragem por conglomerados em múltiplos estágios, cujos dados foram coletados por meio de um questionário em visitas domiciliares. A PRAF foi avaliada por meio da pergunta "Com que frequência você pratica atividade física?". Aqueles que responderam "sempre" ou "frequentemente" foram considerados ativos. Características sociodemográficas, comportamentais e de saúde geral foram avaliadas. Utilizou-se o teste do qui-quadrado e o modelo de regressão de Poisson, com ajuste robusto para as variâncias. Resultados: Entre os adolescentes, 45,2% foram considerados ativos. A PRAF entre adolescentes apresentou associação significativa com: menor idade, sexo masculino, aqueles que estavam estudando, que não fumavam e com maiores níveis de qualidade de vida/ domínio mental. Entre os adultos, 20,7% foram considerados ativos. A PRAF entre adultos apresentou associação significativa com sexo masculino, maior escolaridade e maior nível de qualidade de vida relacionado aos aspectos mentais. Entre os idosos, 19,1% foram considerados ativos. A PRAF entre idosos apresentou associação significativa com cor de pele autodeclarada branca, maior escolaridade, exercer atividade de trabalho e maior nível qualidade vida (aspecto mental). Conclusão: Observou-se um decréscimo do nível de atividade física com o aumento da idade cronológica. Recomenda-se a implantação de políticas públicas que estimulem a prática regular de atividade física nos subgrupos populacionais mais afetados pelo sedentarismo: os adultos e os idosos, especialmente as mulheres e os com menor nível socioeconômico.Palavras-chave: atividade física, prevalência, adolescente, adulto, idoso. ABSTRACT Introduction: The regular practice of physical activity (RPAP) is fundamental in any age and has been considered a means of preserving and improving the health and quality of life of the human being. Physical inactivity is a major risk factor for chronic diseases

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