Green tea (GT) has been studied for its effects as antioxidant and cancer-preventive agent. Epidemiological studies showed that GT consumption decreases the risk for prostate cancer (PC). To investigate whether erythrocyte oxidative stress (OS) is associated with PC and whether daily consumption of GT improves the oxidative phenotype, we performed a study in a group of Algerian PC patients, preceded by an in vitro study to characterize composition and antioxidant/antiproliferative activities of the GT used. This contained a high content of phenolic and flavonoid compounds, demonstrating in vitro antioxidant activity and significant antiproliferative effect on human prostate cancer PC-3 cell line. Seventy PC patients and 120 age-matched healthy subjects participated in the study, with glutathione (GSH), malondialdehyde (MDA), and catalase activity evaluated before and after GT consumption. The results showed a reduced GSH and catalase activity and a high level of MDA in erythrocytes from PC patients. The consumption of 2-3 cups per day of GT during 6 months significantly increased GSH concentration and catalase activity and decreased MDA concentration. In conclusion, GT significantly decreased OS in Algerian PC patients. Regular consumption of GT for a long period may prevent men from developing PC or at least delay its progression.
The objective of the current study was led to reveal the possible protective effects of n-butanol extract of Helianthemum
confertum (H. confertum) against doxorubicin (DOX) induced liver damage and its implication on the integrity of liver
cells. Adult male rats were randomly divided into groups treated with plant extract (50 mg/kg, 100 mg/kg) for 10 days
and/or injected with a single dose of DOX (10 mg/kg). Liver function as well as oxidative stress parameters and histological
study were estimated. DOX treated rat’s induced hepatic dysfunction revealed by a significant increase in biochemical
parameters (serum transaminases, cholesterol and triglycerides) and disturbance in oxidative stress parameters described
by an increase in malondialdehyde (MDA) levels, providing information on the loss of cellular integrity. This later elicited
histopathological changes in the liver which was confirmed on histological section chowing necrotic cells. Altghout the
DOX-treatment reduced significantly the reduced glutathione (GSH) level and the glutathione peroxidase (GPx) activity.
The pretreatment of the animals with n-butanol extract of H. confertumat 50 mg/kg and 100 mg/kg counteracted almost all
adverse effects induced by DOX. The results showed a considerable decrease in serum markers of liver function and lipid
peroxides. There was significant increase in the GSH level and the activity of antioxidant enzyme (GPx), which allowed
the normalization of redox status in liver cells. Data suggest that DOX-induced an oxidative stress in rat’s liver and nbutanol
extract of H. confertum exerted antioxidant properties.
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