A reusable miniature silicon sensor for prostate-specific antigen (PSA) is implemented. A micro-machined cantilever beam is fabricated as the basis of this sensor by photo-lithography. An 8-bit successive approximation analog-to-digital converter (SAR ADC) and an on-off-keying digital wireless transmitter are integrated to enable wireless data transmission. The detectable PSA solution ranges from 0.1 ug/ml to 200 ug/ml. Wireless interface is fabricated with TSMC 0.35 um 2P4M CMOS technology.Index Terms -prostate-specific antigen, cantilever beam, on-off-keying, successive approximation, analog-to-digital converter, position-sensitive detector.
A novel reusable biosensor of label-free biomolecular recognition based on the nano-mechanics transduction in a micro-fabricated cantiIever has been developed. The nanomechanics-based immunoassay biosensor was proven to be repeatedly used with desorption of the pre-bound antigen-antibody by an in-situ alternative electrical field. This new approach of electric manipulation in separating the antigen out of the antibody in a buffer fluid environment was confirmed in nanomechanics-based immunoassay biosensor in which a conventional desorption is long used with high concentrated acid solution in a range of pH 2-3. The potential benefit of the electrical means over a conventional pre-bound antigen-antibody desorption of strong acid solution is to maintain long-standing protein activity in multiple uses such that the micro biosensor is reliable and reproducible in every detection. The complete sensing history from a monolayer of bivlinker, to antibody and antigen is also fmt demonstrated in nanomechanics-based immunoassay.
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