No positive evidence could be found for the appearance in urine from either normal people or schizophrenics of 3,4-dimethoxyphenylethylamine, p-methoxyphenylethylamine, 3,4-dimethoxyphenylacetic acid, or p-methoxyphenylacetic acid. It was confirmed that these amines when ingested are excreted largely as the acids so that failure to find the acids in urine in detectable amounts (10 μg/24 h) indicates that the amines, if present at all, would be far below the limits detectable by the methods used (5 μg/24 h). The discrepancy between this and previous reports may depend on the particular urine specimens studied but is more likely a reflection of resolution difficulties in gas, paper, and thin-layer chromatography. Ninety percent of the radioactivity of administered p-tyramine-2-14C was accounted for in the urine with no evidence of any p-methoxylated derivative. Various common foodstuffs do not contain detectable amounts of these p-methoxylated amines or acids.
Trials were conducted to evaluate the anthelmintic effect of a combination of epsiprantel at a dose rate of 5.5 mg/kg bodyweight and pyrantel pamoate at 5 mg pyrantel base/kg against Toxocara canis in prenatally infected unweaned greyhound pups, Toxascaris leonina, Uncinaria stenocephala, Trichuris vulpis and Dipylidium caninum in naturally infected adolescent greyhounds and Ancylostoma caninum, U stenocephala, Taenia hydatigena and Taenia pisiformis in artificially infected laboratory beagles. The product was well accepted and produced no obvious side effects. Percentage efficacy values based on post mortem worm counts were: T hydatigena 100; T pisiformis 100; D caninum 100; adult T canis 84.0; adult T leonina 96.5; immature T leonina 99.8; U stenocephala 99.0 and 87.7; A caninum 92-7; and T vulpis 43.3.
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