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Monitoring serum/plasma concentrations of lamotrigine may be useful under certain circumstances. An HPLC column packed with strong cation-exchange (SCX)-modified microparticulate silica together with a 100% methanol eluent containing an ionic modifier permits direct injection of sample extracts. An HPLC-UV method developed using this principle for the measurement of serum/plasma lamotrigine is simple, sensitive and selective. The analysis time is less than 5 min. Intra- and inter-assay precision and accuracy meet acceptance criteria, and sample stability, and potential interferences from other compounds have been evaluated. There was good agreement with consensus mean results from external quality assessment samples (n = 32). Analysis of patient samples (n = 115) using the HPLC method and the Seradyn QMS® Lamotrigine immunoassay showed that the immunoassay over-estimated lamotrigine by 21% on average.

Using a LiF dosimeter, comparative measurements were carried out on film mammography and xeromammography on surface and exit dose to the breast and scatter at the level of the gonads. Exit dose at 200 to 330 mR was approximately the same for both methods; incident dose at 6,800 mR for film mammography was significant higher than for xeromammography at 3,800 mR (Mo tube) or 1, 200 mR (tungsten tube). Scatter at the level of the gonads for all three methods was between 4.4 and 12.8 mR. For xeroradiography of the knee joint, the radiation dose of 466 mR was approximately three times that for a film technique (160 mR).

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