Biomaterial-based regenerative approaches would allow for cost-effective off-the-shelf solution for the treatment of wounds. Hyaluronan (HA)-based hydrogel is one attractive biomaterial candidate because it is involved in natural healing processes, including inflammation, granulation, and reepithelialization. Herein, dynamic metal-ligand coordination bonds are used to fabricate moldable supramolecular HA hydrogels with self-healing properties. To achieve reversible crosslinking of HA chains, the biopolymer is modified with pendant bisphosphonate (BP) ligands using carbodiimide coupling and chemoselective "click" reactions. Hydrogel is formed immediately after simple addition of silver (Ag ) ions to the solution of HA containing BP groups (HA-BP). Compared with previous HA-based wound healing hydrogels, the HA-BP·Ag hydrogel is highly suitable for clinical use as it can fill irregularly shaped wound defects without the need for premolding. The HA-BP·Ag hydrogel shows antimicrobial properties to both Gram-positive and Gram-negative bacterial strains, enabling prevention of infections in wound care. In vivo evaluation using a rat full-thickness skin wound model shows significantly lower wound remaining rate and a thicker layer of regenerated epidermis as compared with the group left without treatment. The presented moldable and self-healing supramolecular HA hydrogel with "ready-to-use" properties possesses a great potential for regenerative wound treatment.
The diffusion behavior of lithium (Li) ions on solid-electrolyte interphase (SEI) is fundamentally essential to Li metal batteries, whereas the underlying microscopic mechanism is still indistinct. What are the main...
Exploiting effective electrocatalysts based on elaborate heterostructures for the oxygen evolution reaction (OER) has been considered as a promising strategy for boosting water splitting efficiency to produce the clean energy—hydrogen. However, constructing catalytically active heterostructures with novel composition and architecture remains poorly developed due to the synthetic challenge. In this work, it is demonstrated that unique Ni(CN)2/NiSe2 heterostructures, composed of single‐crystalline Ni(CN)2 nanoplates surrounded by crystallographically aligned NiSe2 nanosatellites, can be created from nickel‐based Hofmann‐type coordination polymers through stepwise topochemical pathways. When employed as the OER electrocatalyst, the Ni(CN)2/NiSe2 heterostructures show enhanced performance, which could be attributed to optimized geometric and electronic structures of the catalytic sites endowed by the synergy between the two components. This work demonstrates a rational synthetic route for creating a novel Ni‐based OER electrocatalyst that possesses nanoscale heterostructure, whose composition, spatial organization, and interface configuration can be finely manipulated.
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