[Abstract unavailable

These results indicate that diabetes has become a major public health problem in China and that strategies aimed at the prevention and treatment of diabetes are needed.

Urothelial carcinoma of the bladder is a common malignancy that causes approximately 150,000 deaths per year worldwide. To date, no molecularly targeted agents have been approved for the disease. As part of The Cancer Genome Atlas project, we report here an integrated analysis of 131 urothelial carcinomas to provide a comprehensive landscape of molecular alterations. There were statistically significant recurrent mutations in 32 genes, including multiple genes involved in cell cycle regulation, chromatin regulation, and kinase signaling pathways, as well as 9 genes not previously reported as significantly mutated in any cancer. RNA sequencing revealed four expression subtypes, two of which (papillary-like and basal/squamous-like) were also evident in miRNA sequencing and protein data. Whole-genome and RNA sequencing identified recurrent in-frame activating FGFR3-TACC3 fusions and expression or integration of several viruses (including HPV16) that are associated with gene inactivation. Our analyses identified potential therapeutic targets in 69% of the tumours, including 42% with targets in the PI3K/AKT/mTOR pathway and 45% with targets (including ERBB2) in the RTK/MAPK pathway. Chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any common cancer studied to date, suggesting the future possibility of targeted therapy for chromatin abnormalities.

Advanced thermoelectric technology offers a potential for converting waste industrial heat into useful electricity, and an emission-free method for solid state cooling. Worldwide efforts to find materials with thermoelectric figure of merit, zT values significantly above unity, are frequently focused on crystalline semiconductors with low thermal conductivity. Here we report on Cu(2-x)Se, which reaches a zT of 1.5 at 1,000 K, among the highest values for any bulk materials. Whereas the Se atoms in Cu(2-x)Se form a rigid face-centred cubic lattice, providing a crystalline pathway for semiconducting electrons (or more precisely holes), the copper ions are highly disordered around the Se sublattice and are superionic with liquid-like mobility. This extraordinary 'liquid-like' behaviour of copper ions around a crystalline sublattice of Se in Cu(2-x)Se results in an intrinsically very low lattice thermal conductivity which enables high zT in this otherwise simple semiconductor. This unusual combination of properties leads to an ideal thermoelectric material. The results indicate a new strategy and direction for high-efficiency thermoelectric materials by exploring systems where there exists a crystalline sublattice for electronic conduction surrounded by liquid-like ions.

Severe hypoglycemia was strongly associated with increased risks of a range of adverse clinical outcomes. It is possible that severe hypoglycemia contributes to adverse outcomes, but these analyses indicate that hypoglycemia is just as likely to be a marker of vulnerability to such events. (Funded by Servier and the National Health and Medical Research Council of Australia; ClinicalTrials.gov number, NCT00145925.).

A measurement of the Higgs boson mass is presented based on the combined data samples of the ATLAS and CMS experiments at the CERN LHC in the H → γγ and H → ZZ → 4l decay channels. The results are obtained from a simultaneous fit to the reconstructed invariant mass peaks in the two channels and for the two experiments. The measured masses from the individual channels and the two experiments are found to be consistent among themselves. The combined measured mass of the Higgs boson is m H ¼ 125.09 AE 0.21 ðstatÞ AE 0.11 ðsystÞ GeV. DOI: 10.1103/PhysRevLett.114.191803 PACS numbers: 14.80.Bn, 13.85.Qk The study of the mechanism of electroweak symmetry breaking is one of the principal goals of the CERN LHC program. In the standard model (SM), this symmetry breaking is achieved through the introduction of a complex doublet scalar field, leading to the prediction of the Higgs boson H [1-6], whose mass m H is, however, not predicted by the theory. In 2012, the ATLAS and CMS Collaborations at the LHC announced the discovery of a particle with Higgs-boson-like properties and a mass of about 125 GeV [7][8][9]. The discovery was based primarily on mass peaks observed in the γγ and ZZ → l þ l − l 0þ l 0−(denoted H → ZZ → 4l for simplicity) decay channels, where one or both of the Z bosons can be off shell and where l and l 0 denote an electron or muon. With m H known, all properties of the SM Higgs boson, such as its production cross section and partial decay widths, can be predicted. Increasingly precise measurements [10][11][12][13] have established that all observed properties of the new particle, including its spin, parity, and coupling strengths to SM particles are consistent within the uncertainties with those expected for the SM Higgs boson.The ATLAS and CMS Collaborations have independently measured m H using the samples of proton-proton collision data collected in 2011 and 2012, commonly referred to as LHC Run 1. The analyzed samples correspond to approximately 5 fb −1 of integrated luminosity at ffiffi ffi s p ¼ 7 TeV, and 20 fb −1 at ffiffi ffi s p ¼ 8 TeV, for each experiment. Combined results in the context of the separate experiments, as well as those in the individual channels, are presented in Refs. [12,[14][15][16].This Letter describes a combination of the Run 1 data from the two experiments, leading to improved precision for m H . Besides its intrinsic importance as a fundamental parameter, improved knowledge of m H yields more precise predictions for the other Higgs boson properties. Furthermore, the combined mass measurement provides a first step towards combinations of other quantities, such as the couplings. In the SM, m H is related to the values of the masses of the W boson and top quark through loopinduced effects. Taking into account other measured SM quantities, the comparison of the measurements of the Higgs boson, W boson, and top quark masses can be used to directly test the consistency of the SM [17] and thus to search for evidence of physics beyond the SM.The combination is performed usin...

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