Nanosuspension can be defined as colloidal dispersions of Nano-sized drug particles that are produced by a suitable method and stabilized by a suitable stabilizer. They can also define as the biphasic system consisting of pure drug particle dispersed in an aqueous vehicle in which the diameter of the suspended particle is less than 1µm in size. Techniques of drug Nanosuspension preparation can be categorized into two principle classes; Top-down and bottom-up technologies. The top-down technologies are the mechanical communication processes of larger drug particles, as in milling and homogenization. The bottom-up technologies begin with the molecules which are dissolved and then precipitated through on solvent addition a in supercritical fluid technology, spray freezing in to liquid process, evaporative precipitation into aqueous solution and liquid solvent change process. Although top-down approaches are widely employed, the drawbacks associated with mechanical attritions processes, such as time consumption, intensive energy use, inadequate control of particles size and electrostatic effects, promote greater interest toward bottom up creation of nanoparticles. Nano means it is the factor of 10 -9 . The particle size distribution ranges from 0.1µm to 25µm, only negligible amount being below 1µm in the manometer range. For a long duration of time micronization of poorly soluble drugs by colloidal mills was prepared. Different Methods for Preparation of Nanosuspension [1]Mainly there are two methods for preparation of Nanosuspension. The conventional methods of precipitation are called Bottom up Technology. In Bottom up Technology the drug is dissolved in a solvent, which is then added to non-solvent to precipitate the crystal. This technique is that during the precipitation procedure the growing of the drug crystals need to be controlled by addition of surfactant to avoid formation of micro particles. The top down Technologies are the disintegration methods and are preferred over the precipitation methods. The top
The success of an ocular delivery system is dependent on the reduction in the precorneal loss of the drug by prolonging the contact time and increasing permeability across the corneal barrier which makes the drug more bioavailable to the ocular tissue. The current investigation aimed to improve the transcorneal permeation of ciprofloxacin hydrochloride by loading into liposomes. The liposomes were prepared and investigated the role of surface charge and nonionic surfactants on the permeation of ciprofloxacin from liposomes across isolated corneal membrane. Among the formulations tested, the liposomes containing stearylamine and polysorbate 80 exhibited higher transcorneal permeation compared to other formulations. A two fold increase in the flux and enhancement ratio was observed for these formulations. The corneal hydration levels tested for the liposomal formulations were within the limits. The data reveals the potential of positive charge and nonionic surfactants in successful delivery of ciprofloxacin across the corneal barrier.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.