The present research paper attempts to study the effect of different process parameters on the dissolution rate during 3D printed tablets. Three-dimensional printing has the potential of serving tailored made tablets to cater personalized drug delivery systems. Fluorescein loaded PVA filaments through impregnation route was used to fabricate tablets based on Taguchi based design of experimentation using Fused Deposition Modelling (FDM). The effect of print speed, infill percentage and layer thickness were analyzed to study the effect on rate of dissolution. Infill percentage followed by print speed were found to be critical parameters affecting dissolution rate. The data analysis provided an insight into the study of interaction among different 3D printing parameters to develop an empirical relation for percentage release of the drug in human body.
Cardiovascular complications are the foremost concern in patients undergoing anticancer therapy. There is an unmet need to address the problems arising from the drug-induced toxicity for the long-term benefit of the patients undergoing chemotherapy. Alternative medicines are gaining their prosperity in addressing the various drug-induced organ toxicity. Dillenia pentagyna Roxb (DP) is an ethnomedicinal plant rich in flavonoids and phenolic contents. In India & Nepal, DP is a common ingredient of traditional medicines used to treat multiple ailments like inflammation, cancer, and diabetes. However, its protective role against doxorubicin (Dox) induced cardiotoxicity remains unexplored. Herein, we investigated the potential effects of various extracts/fractions obtained from the DP’s bark against Dox-induced cardiotoxicity, both in-vitro and in-vivo. The anti-oxidant content of the extracts/fractions was evaluated by using DPPH, ABTS and FRAP chemical assays. The results indicated that the hydroalcoholic (HA) extract of DP has intense anti-oxidant potential. Further fractionation of DP revealed that the phenolic-rich fraction (F1) has a high anti-oxidant potential. The protective effect of extract/fraction was also investigated in the H9c2 cell line following the Dox-induced cardiotoxicity model. We observed that the pre-treatment of extract/fraction in cardiomyocytes had exhibited increased cell viability. Fluorescence-based chemical assays indicated a decreased ROS levels in the treated groups in comparison to the Dox control group. The effect of DP was evaluated further in balb/c mice by the Dox-induced cardiotoxicity model. Non-invasive techniques like high-frequency ultrasonography and electrocardiogram revealed that the mice pre-treated with DP had improved cardiac functionality (left ventricular ejection fraction and stroke volume) and normalized the electrocardiograms compared to the Dox control group. Further, biochemical analysis with the cardiac tissues revealed that the cytoprotective proteins like HO-1, SOD-2, and Nrf-2 were elevated in the DP treated groups compared to the Dox control group. Overall, our results suggested that the bioactive extract/fractions of DP helped alleviate the Dox-induced cardiotoxicity. LC-QTOF-ESI-MS analysis of DP and F1 indicated that polyphenolic anti-oxidant compounds like gallic acid, syringic acid, and sinapic acid could be responsible for the potent -cardioprotective effect. Future understanding of the pharmacokinetics and pharmacodynamic parameters can help translate from the bench to the bedside.
In this paper a laminated waveguide fed DR Antenna is investigated. It can use for moderate power military applications. Cylindrical DRA is excited by two closely spaced asymmetric longitudinal slots on the broad wall of the laminated cavity are responsible for producing three different frequency bands. Parametric study of slots has been done with the help of commercial software ANSOFT HFSS. All the bands have sharp rejection. The final model of the antenna is simulated, fabricated and experimentally measured. Measured results are in quite accordant with design results. SIW feeding structures have small losses, moderate power handling capacity, low costs, compact sizes and can be seamlessly integrated with planar circuits. At all the bands 9.76 GHz, 10.53 GHz and 11.8 GHz resonant frequency, the antenna shows 56 MHz, 160 MHz, and 250 MHz impedance bandwidth (for VSWR<2) with 6 dB,6.2 dB and 6.8 dB gain respectively. Simulated and measured results reveal outstanding performance with a cross-polar level of 29 dB lower than that of the co-polar level at 9.76 GHz, the cross-polar level of 32 dB lower than that of the co-polar level at 10.53, GHz, and similarly cross-polar level of 30 dB lower than that of the co-polar level at 11.8 GHz.
are available for estimation of Tenofovir. [2-5] Hence, the proposal to estimate Tenofovir disoproxil fumarate by the UV spectroscopic method. MATERIALS AND METHODS Instrument used UV-visible spectrophotometer (Elico 210) 10 mm quartz cell and spectral bandwidth 1 nm. Reagent used Triple distilled water.
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