Cationic nanoparticles (NPs) are preferred for therapeutic applications due to its better uptake by mammalian cells. However, preparing cationic polymeric NPs with stability in wide pH range along with limited toxicity remains a challenge. Dextrin, a carbohydrate‐based natural biological macromolecule holds great potential in biomedical applications. Further, it is an inexpensive and abundant raw material which has high pH stability making it more advantageous over other widely explored macromolecules like chitosan. Herein, we report a simple process for preparing biocompatible cationic dextrin (CD) NPs. A series of CDs were prepared through a single‐step reaction by incorporating quaternary ammonium groups onto the polymeric backbone using varying amount of glycidyltrimethylammonium chloride. Formation of uniform spherical CD NPs having size within 100 nm were achieved by a facile synthesis process of ionic gelation using a biocompatible cross‐linker sodium tripolyphosphate. The prepared CD NPs remained stable across the pH range of 5.5–11 and demonstrated approximately 75% cellular internalization within 6 h. The CD NPs were also found to be both cytocompatible and hemocompatible. Next, the chemotherapeutic drug doxorubicin was encapsulated within CD NPs, which is one of the most common chemotherapeutic agents used for the treatment of various types of cancers including breast, lung, ovarian and bladder. The Dox‐loaded CD NPs showed better drug release at acidic pH conditions and induced more than 80% cell death within 24 h at just 2 μg/ml concentration when tested against HeLa cell lines, thus, proving to be a potential drug delivery vehicle for cancer therapy applications.
This work describes a new route to thermally stable energetic materials by connecting different types of energetic moieties (nitropyrazole and polynitrobenzene) with C−C bonds, where the first step involves a Suzuki cross‐coupling reaction between 4‐bromo‐3,5‐dinitro‐1H‐pyrazole and 4‐chlorophenylboronic acid. Further nitration, amination, oxidation, and salt formation reactions on the resulting C−C coupled framework resulted in various thermally stable energetic materials. All the compounds were fully characterized using IR, NMR [1H, 13C{1H}], differential scanning calorimetry (DSC), elemental analysis, and HRMS studies. Compounds 7 and 9 were further characterized by 15N NMR, and compounds 3 and 6 were characterized by single‐crystal X‐ray diffraction studies. Theoretical heats of formation and energetic performance for all the energetic compounds were calculated using Gaussian 09 and EXPLO5 v6.06 programs, respectively. This research introduces a novel method for synthesizing C−C coupled energetic materials that are not accessible by any other routes.
A new class of heat-resistant explosives was synthesized by coupling N-methyl-3,5-dinitropyrazole with polynitrobenzene moieties through carbon-carbon bonds. Simple Pd(0) based Suzuki cross-coupling reactions between N-methyl-4-bromo-3,5-dinitropyrazole and 4-chloro/3-hyrdroxy-phenylboronic acid followed by...
Magneto-fluorescent nanoparticles have spellbound great attention because of their dual nature as an multimodal imaging probe in various biomedical applications. Particulary, it is desirable to understand how these nanoparticles interact...
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