The pharmaceutical industry has invested a great deal of time and finance in the development of therapeutics targeting amyloid generation, signalling and plaque stability. This has been based on the amyloid cascade hypothesis which states that abnormal amyloid precursor protein processing and the formation of amyloid plaques is the central process in the development of the symptoms of Alzheimer's disease. However, most clinical trials in this area have been disappointing; therefore the attendees of the Models of Dementia: the Good, the Bad and the Future meeting were given the opportunity to openly debate the proposal 'the amyloid cascade has misled the pharmaceutical industry', with the main contributions from Professor John Hardy and Professor John Mayer. The present article is a representation of the debate.

IUPAC-IUB Commission on Biochemical Nomenclatured CONTENTS I. Fatty acids, neutral fats, long-chain alcohols and long-chain bases A. Generic terms (Lip-1.1-1.5). B. Individual compounds. 1. Fatty acids and alcohols (Lip-1.6-1.7). 2. Sphinganine and derivatives (Lip-1.8-1.11) 3. Glycerol derivatives (Lip-1.12-1.13) C. Symbols and abbreviations (Lip-1.14-1.18). II. Phospholipids. A. Generic terms (Lip-2.1-2.10) B. Individual compounds (Lip-2.11-2.12) III. Glycolipids. A. General considerations B. Generic terms (Lip-3.1-3.5). C. Individual compounds (Lip-3.6-3. 12). D. Symbols and abbreviations (Lip-3.12-3.14). IV. Neuraminic acid (Lip-4.1-4.3). Appendix A: names of and symbols for higher fatty acids. Appendix B: symbols recommended for various constituents of lipids Appendix C: abbreviated representation of gangliosides a Documentc of the IUPAC-IUB Commission on Biochemical Nomenclature (CBN) approved by IUPAC and IUB in 1976, and published with the cooperation of the IUB Commission of Editors of Biochemical Journalsd. Comments on these Recommendations and suggestions for future revisions may be sent to any member of CBNd. b These Recommendations are a revision and extension of "The Nomenclature of Lipids", which appeared in 1967, as amended in 197011' Vol. 171 c Reprints of this document, supplied by the publishing journals, may be obtained from W. E. Cohn

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A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids By M. K. GAITONDE Volume 104 (1967) p. 628, column 1, line 6:for (sp.gr. 1-36) read (sp.gr. 1.18) The thiol sequences and sub-units of light meromyosin fraction 1 By A. G. WEEDS Volume 104 (1967) p. 44P, column 2, lines 35 and 36: the sequence for the larger variety of peptide Ti should read: Thr

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The revised Tentative Rules published by CBN in 1966 (1) were an attempt to achieve a broad systematization of various types of abbreviated notation already in use [e.g., Brand & Edsall (1947) Annu. Rev. Biochem.; Report of the Committee on Abbreviations of the American Society of Biological Chemists, 18 December 1959; Report of the Committee on Nomenclature of the European Peptide Symposium (1963) pp. 261-269, Pergamon Press, Oxford; 'Tentative Rules for Abbreviations and Symbols of Chemical Names of Special Interest in Biological Chemistry' (2)]. They sought to reconcile the needs of the protein chemist, i.e., indication of amino-acid sequences, with those of persons concerned more with the chemical reactions of proteins and the synthesis of polypeptides, i.e., the need for conveying more detailed chemical information in abbreviated form. Recent progress in the field of peptide synthesis and in the chemical modification of proteins has made necessary a revision of these Tentative Rules. This revision has been aided by the work of an expert group consisting of J.