Heterocyclic compounds play a tremendous role in the field of medicinal chemistry due to their association with diverse pharmacological properties. Most of the pharmaceutical drugs used in medicines possess a wide range of heterocyclic nucleus. It was decided basis on literature studies that various synthetic protocols like microwave‐assisted, nanocatalysed, green synthesis, click reaction, and multicomponent routes could be used for the betterment of the purity of products, selectivity, and better yields of the products. We have focused attention on the development of synthetic strategies of the above‐mentioned moieties because N‐, O‐ and S‐ containing heterocyclic compounds have seemed owing to a wide diversity of their biological activities viz. antioxidant, anticancer, anticonvulsant, anti‐inflammatory, neuroprotective, antiproliferative, anti‐obesity, antihyperglycemic, antihypercholesteroler, antiulcer, antidiabetic, antileishmanial, antitrypanosomal, antibiotic, etc. In this review article, an overview of the applications of synthetic protocols for the preparation of five‐membered and six‐membered heterocyclic compounds containing two or more heteroatoms (O, N, S) at different‐different positions along with their different potent and competent candidates against various diseases is presented in last 10–15 years.
High power density and long cyclic stability are important characteristics that make supercapacitor suitable for many industrial applications. Measurement of equivalent series resistance and capacitance, is a general way to investigate performance of the Electric Double Layer Capacitor (EDLC). In this work, a Panasonic EDLC (10F) was investigated under cyclic degradation and monitored using electrochemical impedance spectroscopy (EIS) characterisation and Randles circuit model. After fitting, it was observed that series resistance was increased up to 80% and parallel capacitance was decreased up to 22%. The EIS data were validated using Kramers‐Kronig Transformation to check causality, linearity, and stability in the system.
An efficient, environmentally benign and novel method for the synthesis of phenacyl halides as antiplatelet agents has been reported in the presence of nanocatalyst (TiO2) by using N‐halosuccinimides (NXS, X=Cl, Br) as a source of halogen and tert‐Butyl Hydrogen Peroxide (TBHP) under microwave irradiation. Compound 2a showed best in vitro antiplatelet activity with 540 and 480 sec as clotting time in prothrombin time (PT) and activated partial thromboplastin time (APTT) assay respectively. Rest compounds showed good to moderate activity. Structures of all synthesized compounds were elucidated by IR, NMR and Mass spectrometry.
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