Phyllanthus emblica is an edible nutraceutical and functional food in the Asia area with medicinal and nutritive importance. The fruit extract of P. emblica is currently considered to be one of the effective functional foods for flesh maintenance and disease treatments because of its antioxidative and immunomodulatory properties. We examined the antioxidant abilities of the fruit extract powder by carrying out 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, iron reducing power, and metal chelating activity analysis and showed excellent antioxidative results. In 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the result showed that the samples had no cytotoxic effect on RAW 264.7 cells even at a high concentration of 2 mg/mL. To investigate its immunomodulatory function, our estimation was to treat it with lipopolysaccharide (LPS) in RAW 264.7 cells to present anti-inflammatory capacities. The extract decreased reactive oxygen species (ROS) production levels in a dose-dependent manner measured by flow cytometry. We also examined various inflammatory mRNAs and proteins, including nuclear factor-κB (NF-κB), inducible nitric oxide synthases (iNOS), and cyclooxygenase-2 (COX-2). In quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blotting assay, all three targets were decreased by the extract, also in a dose-dependent manner. In conclusion, P. emblica fruit extract powder not only lessened antioxidative stress damages, but also inhibited inflammatory reactions.
We have constructed dual sensing platforms based on the combination of a plasma separation pad and GOD-GO/MnO2 for direct detection of glucose concentration in whole blood by colorimetric assay without blood sample pretreatment and dilution.
Natural products are favored because of their non-toxicity, low irritants, and market reacceptance. We collected examples, according to ancient wisdom, of natural products to be applied in transdermal delivery. A transdermal delivery system, including different types of agents, such as ointments, patches, and gels, has long been used for skin concerns. In recent years, many novel transdermal applications, such as nanoemulsions, liposomes, lipid nanoparticles, and microneedles, have been reported. Nanosized drug delivery systems are widely applied in natural product deliveries. Nanosized materials notably enhance bioavailability and solubility, and are reported to improve the transdermal permeation of many substances compared with conventional topical formulations. Natural products have been made into nanosized biomaterials in order to enhance the penetration effect. Before introducing the novel transdermal applications of natural products, we present traditional methods within this article. The descriptions of novel transdermal applications are classified into three parts: liposomes, emulsions, and lipid nanoparticles. Each section describes cases that are related to promising natural product transdermal use. Finally, we summarize the outcomes of various studies on novel transdermal agents applied to skin treatments.
This study has been prepared within the UNU-WIDER project on 'SOUTHMOD-Simulating Tax and Benefit Policies for Development' which is part of the Institute's larger research project on 'The economics and politics of taxation and social protection'.
When the World Health Organization (WHO) analyzed the culprits of global warming, it was found that in developed countries with relatively few high-polluting heavy industries, the medical sector is one of the sources of high-density carbon emissions. Therefore, the medical industry has a noticeable impact on the environment. Amid the current COVID-19 epidemic, this study adopts the theory of planned behavior (TPB), widely used in decision-making science. We selected a regional teaching hospital with 339 employees in Taiwan to obtain valid questionnaire data. We explore the comparative analysis of different intra-organizational stakeholders’ “attitudes,” “subjective norms,” and “perceived behavioral control” on the hospital’s behavioral intention to promote green healthcare. The results show that the TPB model has reliable explanatory power. All three factors have a positive and significant effect on promoting green hospital behavior. Among them, perceived behavioral control was the most notable. A comparative analysis of the differences among stakeholders in the research model shows that “medical administrators” and “nursing staff” have a higher proportion of significant influence effects in various hypotheses, highlighting the critical roles of these two groups in promoting green hospitals. This research policy suggests that the cross-departmental staff in the hospital put forward green innovation ideas, strengthen internal environmental education and management, establish a good incentive system for front-line nursing staff, and implement the sustainable development strategy of the hospital.
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