95% CIe340 e À5.1, p = 0.04), yet higher overall incidence of post-operative pancreatic fistula (POPF) (RR = 2.08, 95% CI 1.39e3.12, p < 0.01), and also higher incidence of clinically relevant POPF grades B/C (RR = 1.32, 95% CI 0.98e1.77, p = 0.07). There was no statistically significant difference between the two groups in hospital stay, post-operative hemorrhage, wound infection, and overall morbidity. Subgroup analysis of studies that included only nf-pNET patients showed similar trends to overall analysis. Conclusions: Enucleation for pNETs is performed in shorter time with less blood loss yet with more incidence of POPF. Prospective trials are needed to accurately compare oncologic and long term outcomes.
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