The E,Z-configured 1,3-diene unit is a common motif in numerous bioactive natural products. Although several powerful methods are available to produce these motifs with high levels of selectivity, their construction within a complex, polyfunctionalised structure, such as a natural product, requires well-defined strategies to avoid undesirable reactions and low-to-moderate selectivities. The aim of this review is to provide a full account of the stereoselective strategies for building E,Z-configured 1,3-dienes, as well as to highlight selected total syntheses that employ them. 2.3. Heck Reactions 2.4. CÀ H activation reactions 2.5. Ir-Catalysed Olefinations 2.6. Carbonyl Olefination Reactions 2.7. Elimination Strategies 2.8. Double Bond Isomerisation Strategies 2.9. Metathesis Strategies 2.10. Ene-Yne Triple Bond Reduction Strategies 2.11. Organocatalysed 1,6-Michael Additions 3. Applications in Total Synthesis: Selected Examples 4. Conclusion
The front cover picture illustrates the diverse chemical building blocks and synthetic methods, including transition metal‐catalysed methodologies, that have been developed over the past decades to generate (E,Z)‐diene moieties. Many of the methodical developments were applied in total synthetic approaches of complex natural products containing one or more (E,Z)‐diene moieties. The review provides a full account of stereoselective strategies to build up E,Z‐configured 1,3‐dienes. Details can be found in the review by Renata Marcia de Figueiredo and collaborators. (P. Hubert, E. Seibel, C. Beemelmanns, J.‐M. Campagne, R. M. de Figueiredo, Adv. Synth. Catal. 2020, 362, 5532–5575; DOI: 10.1002/adsc.202000730).
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