Background: Prevalence of CRKP bloodstream infection with high mortality has attached physicians' attention. High-VAT and high-SAT were confirmed by previous studies that closely related to increased pneumonia severity, more complications, and higher mortality in COVID-19. Thus, we speculate that CT-quantified body composition may also be connected to all-cause mortality and bacterial clearance in patients with CRKP bloodstream infection. Methods: We investigated the associations of CT-quantified body composition with CRKP bloodstream infectious patients. All of the CT images were obtained at the level of the L3/4 spinal level. The prognostic value of the body composition was analyzed using the Cox regression model, and precise clinical nomograms were established. Results: Factors associated with 30-day all-in hospital mortality included TAT [adjusted odds ratio (OR)=1.028, 95% confidence interval (CI), 1.004–1.053; p = 0.028], age [OR=1.031, 95% CI, 1.001–1.062; p = 0.046] and SOFA score [OR=1.137, 95% CI 1.047–1.235; p = 0.002]. Compared with low-VAT, patients with high-VAT show a strikingly poor prognosis in both 30-day mortality (P=0.0449, Figure 2A) and all-cause mortality (P=0.0048, Figure 2C). The results of TAT were similar with VAT. Conclusions: Our study suggests that CT-derived composition could be a credible and effective alternative to assess the prognosis of patients with BSIs owing to CRKP. CT-quantified total adipose tissue, age and SOFA scores were independently associated with 30-day all-cause mortality in these severe infectious patients, while skeletal muscle did not have obvious statistical significance.
Background Prevalence of CRKP bloodstream infection with high mortality has attached physicians' attention. High-VAT and high-SAT were confirmed by previous studies that closely related to increased pneumonia severity, more complications, and higher mortality in COVID-19. Thus, we speculate that CT-quantified body composition may also be connected to all-cause mortality and bacterial clearance in patients with CRKP bloodstream infection. Methods We investigated the associations of CT-quantified body composition with CRKP bloodstream infectious patients. All of the CT images were obtained at the level of the L3/4 spinal level. The prognostic value of the body composition was analyzed using the Cox regression model, and precise clinical nomograms were established. Results Factors associated with 30-day all-in hospital mortality included TAT [adjusted odds ratio (OR) = 1.028, 95% confidence interval (CI), 1.004–1.053; p = 0.028], age [OR = 1.031, 95% CI, 1.001–1.062; p = 0.046] and SOFA score [OR = 1.137, 95% CI 1.047–1.235; p = 0.002]. Compared with low-VAT, patients with high-VAT show a strikingly poor prognosis in both 30-day mortality (P = 0.0449, Fig. 2A) and all-cause mortality (P = 0.0048, Fig. 2C). The results of TAT were similar with VAT. Conclusions Our study suggests that CT-derived composition could be a credible and effective alternative to assess the prognosis of patients with BSIs owing to CRKP. CT-quantified total adipose tissue, age and SOFA scores were independently associated with 30-day all-cause mortality in these severe infectious patients, while skeletal muscle did not have obvious statistical significance.
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