A simple one‐step approach to generate in situ cross‐linked PNIPAM/gelatin nanofibers has been developed when gelatin and PNIPAM–NHS were electrospun in the presence of the cross‐linking agents 1‐ethyl‐3‐(3‐dimethyl‐aminopropyl)‐1‐carbodiimide hydrochloride (EDC) and N‐hydroxysuccinimide (NHS). The fibers exhibit the thermo‐responsive swelling/deswelling function, monitored under atomic force microscopy (AFM). When an anti‐cancer drug doxorubincin (DOX) was loaded, the fibers were able to release DOX evidently on demand of a temperature raise and the released DOX could effectively lower the viability of human cervical cancer Hela cells.
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