Hybrid quantum mechanics/molecular
mechanics (QM/MM) simulations
have advanced the field of computational chemistry tremendously. However,
they require the partitioning of a system into two different regions
that are treated at different levels of theory, which can cause artifacts
at the interface. Furthermore, they are still limited by high computational
costs of quantum chemical calculations. In this work, we develop the
buffer region neural network (BuRNN), an alternative approach to existing
QM/MM schemes, which introduces a buffer region that experiences full
electronic polarization by the inner QM region to minimize artifacts.
The interactions between the QM and the buffer region are described
by deep neural networks (NNs), which leads to the high computational
efficiency of this hybrid NN/MM scheme while retaining quantum chemical
accuracy. We demonstrate the BuRNN approach by performing NN/MM simulations
of the hexa-aqua iron complex.
A series
of novel hetero[n]circulenes of the first,
second, and the third generation including S and Se heteroatoms for n = 6, 7, 8, and 9 were theoretically designed. Their chemical
and electronic structures were investigated using B3LYP-based computational
method. The interaction energies and electric drift mobilities were
evaluated for model parallel-stacked and parallel-slipped dimer configurations
at the room temperature using the Marcus theory and the Einstein relation.
On the basis of the calculated properties, the second and third generation
of sunflower molecules containing the six-membered central ring are
suggested to be perspective candidates for the construction of organic
p- and n-type semiconductors, respectively. The obtained results were
also compared with the theoretical and published experimental results
for reference α-sexithiophene, [6]circulene (coronene), and
octathio[8]circulene (sulflower) molecules.
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