Melanonychia is a nail pigmentation disorder which is predominantly seen in female patients treated by hydroxyurea; especially in patients with diagnosed myeloproliferative disorders. Hydroxyurea inhibits DNA synthesis through its action on ribonucleoside diphosphate-reductase, and can be lead to dermatological disorders including mucocutaneous side effects and nail disorders such as onycholysis, onychodystrophy, and melanonychia. The pathogenesis of hydroxyurea-induced melanonychia is not clear. We present the cases of 4 female patients that two of four patients with diagnosed as polycythaemia rubravera and two of four patients with diagnosed as essential thrombocytosis who are developed melanonychia during hydroxyurea therapy. It is emphasized that the side effects of chemotherapeutic drugs should asses carefully by observing the clinical historyin hematologic patients and treatment should modify, although the side effects will quickly disappear with the reduction or discontinuation of the drug.
Objective: Angiolymphoid hyperplasia with eosinophilia (ALHE), is presented by multiple pink or red papules and nodules on the head, neck, preauricular area and anterior hairline. Although the lesions are usually asymptomatic, they may rarely accompany pain, pulsation, itching and spontaneous bleeding when is pressed on. The etiopathogenesis of ALHE is related to environmental, allergic, hormonal and immunological factors. Here, the purpose of our study is to review the literature and to observe this vasculo-proliferative disease by reporting two case of ALHE associated with an allergic response, one pregnant one man.Case Report: High serum IgE levels and eosinophilia-rich infiltration on histopathological examination were showed in both of our cases. Additionally, IgE antibody was positive in immunohistochemical examination. These findings support the fact that ALHE lesions may be associated with an allergic response in both of our cases. Conclusion:ALHE, which has a lot of questions in its etiopathogenesis, this disease will be better understood by largescale studies in a large number of studies, so that the appropriate treatment method will be chosen and the recurrences after treatment will be less
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