Objective
To investigate the effect of desferrioxamine (DFO) and dextromethorphan (DXM) combination in animal model of Parkinson's disease (PD).
Methods
The PD was induced in rats through intracerebroventricular administration of 6‐hydroxydopamine (6‐OHDA) using stereotaxic apparatus. The animals were subjected to behavioural assessments and neurobiochemicals estimation followed by immunohistochemistry staining of neuron specific enolase (NSE) in striatum.
Key findings
Desferrioxamine and DXM combination has significantly reversed the catalepsy behaviour and elevated the antioxidant enzymes (SOD, CAT, GSH) and dopamine levels. Interestingly, the level of glutamate, nitric oxide, cytokines (IL‐1β, TNF‐α) and NSE expressions were found to be decreased in striatum region of 6‐OHDA‐administered rats. The combination of DFO and DXM has shown synergism in most of the parameters studied, when compared to per se treatment.
Conclusions
The reversal of catalepsy behaviour represents the protective effect of above combination on dopamine neurons in striatum from 6‐OHDA toxicity. The mechanism of DFO and DXM combination might be attributed through attenuation of glutamate‐induced excitotoxicity in neurons through ameliorating the reactive oxygen species and pro‐inflammatory cytokines release. Treatment with DFO and DXM combination could control the multiple events in the pathogenesis of PD.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.