Introdução: A tuberculose é uma doença infectocontagiosa, causada pela bactéria Mycobacterium tuberculosis, também conhecida por bacilo de Koch. Os exames de imagem como radiografia(RX) e tomografia de tórax(TC) são muito utilizados para diagnóstico, sendo que a tomografia de tórax é mais sensível. Apresentação do caso: xxxxx Discussão: A tuberculose tem incidência e prevalência maiores nos países subdesenvolvidos, com grande relação com subnutrição, pobreza e áreas densamente povoadas. Em paralelo, um estudo de caso-controle realizado na China demonstrou que em pacientes com infecção grave pelo COVID-19, a coinfecção pela Tuberculose foi mais comumente encontrada do que outras comorbidade. Conclusão: A grande semelhança nos sinais e sintomas entre Tuberculose e Covid-19 e o número de pacientes sem diagnósticos prévios corrobora para essa discordância.
RESUMOEste trabalho visa apresentar um caso de uma paciente do sexo feminino, 86 anos, branca, com diagnóstico de CBC em asa nasal direita. Esta patologia tem alta incidência, correspondendo a 75% das neoplasias nasais, e a pirâmide nasal é a região mais acometida. Existem diversas técnicas cirúrgicas descritas disponíveis para correção de defeitos de acordo com a unidade estética acometida. Especificamente na asa do nariz, os retalhos mais comumente utilizados são transposição bilobada, retalho em V-Y, nasogeniano e o frontal. A reconstrução nasal da paciente foi feita em três etapas: na primeira, utilizou-se de retalho frontal oblíquo, na segunda etapa foi feita o afilamento do retalho e na terceira foi realizada a secção do pedículo médio-frontal.
The emergence of SARS-CoV-2 variants with multiple shared mutations has been described to be more transmissible and could affect COVID-19 morbidity and mortality. Some of these variants, known as B.1.1.7 (originally described in the United Kingdom), B1.351 (originally described in South Africa), and P.1 (originally described in Brazil) have rapidly become dominant within their countries and require a vigorous public health response. Whole Genomic sequencing remains the gold standard method to identify the SARS-CoV-2 variant, even though this approach is laborious, time-consuming, and expensive. Here, we have developed a fast and simple SYBR green based real-time RT-PCR assay that identifies a distinct signature affecting the Non-Structural Protein 6 (NSP6), a nine-nucleotides deletion leading to amino acid losses: Δ106S, Δ107G, and Δ108F. This NSP6 signature is present in the variants of concern (VOC) described above (B.1.1.7; B1.351; P.1) and has not been detected in other SARS-CoV-2 lineages.
The emergence of SARS-CoV-2 variants with multiple shared mutations has been described to be more transmissible and could affect COVID-19 morbidity and mortality. Some of these variants, known as B.1.1.7 (originally described in the United Kingdom), B1.351 (originally described in South Africa), and P.1 (originally described in Brazil) have rapidly become dominant within their countries and require a vigorous public health response. Whole Genomic sequencing remains the gold standard method to identify the SARS-CoV-2 variant, even though this approach is laborious, time-consuming, and expensive. Here, we have developed a fast and simple SYBR green-based real-time RT-PCR assay that identifies a distinct signature affecting the Non-Structural Protein 6 (NSP6), a nine-nucleotides deletion leading to amino acid losses: Δ106S, Δ107G, and Δ108F. This NSP6 signature is present in the variants of concern (VOC) described above (B.1.1.7; B1.351; P.1) and has not been detected in other SARS-CoV-2 lineages. The new version has corrections made on the master mix and authorship.
The emergence of SARS-CoV-2 variants with multiple shared mutations has been described to be more transmissible and could affect COVID-19 morbidity and mortality. Some of these variants, known as B.1.1.7 (originally described in the United Kingdom), B1.351 (originally described in South Africa), and P.1 (originally described in Brazil) have rapidly become dominant within their countries and require a vigorous public health response. Whole Genomic sequencing remains the gold standard method to identify the SARS-CoV-2 variant, even though this approach is laborious, time-consuming, and expensive. Here, we have developed a fast and simple SYBR green based real-time RT-PCR assay that identifies a distinct signature affecting the Non-Structural Protein 6 (NSP6), a nine-nucleotides deletion leading to amino acid losses: Δ106S, Δ107G, and Δ108F. This NSP6 signature is present in the variants of concern (VOC) described above (B.1.1.7; B1.351; P.1) and has not been detected in other SARS-CoV-2 lineages.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.