Liver cancer is the sixth most frequently diagnosed cancer and, particularly, Hepatocellular Carcinoma (HCC) represents more than 90% of primary liver cancers. Clinicians assess each patient's treatment on the basis of evidence-based medicine, which may not always apply to a specific patient, given the biological variability among individuals. Over the years, and for the particular case of Hepatocellular Carcinoma, some research studies have been developing strategies for assisting clinicians in decision making, using computational methods (e.g. machine learning techniques) to extract knowledge from the clinical data. However, these studies have some limitations that have not yet been addressed: some do not focus entirely on Hepatocellular Carcinoma patients, others have strict application boundaries, and none considers the heterogeneity between patients nor the presence of missing data, a common drawback in healthcare contexts. In this work, a real complex Hepatocellular Carcinoma database composed of heterogeneous clinical features is studied. We propose a new cluster-based oversampling approach robust to small and imbalanced datasets, which accounts for the heterogeneity of patients with Hepatocellular Carcinoma. The preprocessing procedures of this work are based on data imputation considering appropriate distance metrics for both heterogeneous and missing data (HEOM) and clustering studies to assess the underlying patient groups in the studied dataset (K-means). The final approach is applied in order to diminish the impact of underlying patient profiles with reduced sizes on survival prediction. It is based on K-means clustering and the SMOTE algorithm to build a representative dataset and use it as training example for different machine learning procedures (logistic regression and neural networks). The results are evaluated in terms of survival prediction and compared across baseline approaches that do not consider clustering and/or oversampling using the Friedman rank test. Our proposed methodology coupled with neural networks outperformed all others, suggesting an improvement over the classical approaches currently used in Hepatocellular Carcinoma prediction models.

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Background: Recurrence is an important cornerstone in breast cancer behavior, intrinsically related to mortality. In spite of its relevance, it is rarely recorded in the majority of breast cancer datasets, which makes research in its prediction more difficult. Objectives: To evaluate the performance of machine learning techniques applied to the prediction of breast cancer recurrence. Material and Methods: Revision of published works that used machine learning techniques in local and open source databases between 1997 and 2014. Results: The revision showed that it is difficult to obtain a representative dataset for breast cancer recurrence and there is no consensus on the best set of predictors for this disease. High accuracy results are often achieved, yet compromising sensitivity. The missing data and class imbalance problems are rarely addressed and most often the chosen performance metrics are inappropriate for the context. Discussion and Conclusions: Although different techniques have been used, prediction of breast cancer recurrence is still an open problem. The combination of different machine learning techniques, along with the definition of standard predictors for breast cancer recurrence seem to be the main future directions to obtain better results.

Cyber-security is the practice of protecting computing systems and networks from digital attacks, which are a rising concern in the Information Age. With the growing pace at which new attacks are developed, conventional signature based attack detection methods are often not enough, and machine learning poses as a potential solution. Adversarial machine learning is a research area that examines both the generation and detection of adversarial examples, which are inputs specially crafted to deceive classifiers, and has been extensively studied specifically in the area of image recognition, where minor modifications are performed on images that cause a classifier to produce incorrect predictions. However, in other fields, such as intrusion and malware detection, the exploration of such methods is still growing. The aim of this survey is to explore works that apply adversarial machine learning concepts to intrusion and malware detection scenarios. We concluded that a wide variety of attacks were tested and proven effective in malware and intrusion detection, although their practicality was not tested in intrusion scenarios. Adversarial defenses were substantially less explored, although their effectiveness was also proven at resisting adversarial attacks. We also concluded that, contrarily to malware scenarios, the variety of datasets in intrusion scenarios is still very small, with the most used dataset being greatly outdated.