BackgroundCationic antimicrobial peptides (CAMPs) are attractive scaffolds for the next generation of antimicrobial compounds, due to their broad spectrum of activity against multi-drug resistant bacteria and the reduced fitness of CAMP-insensitive mutants. Unfortunately, they are limited by poor in vivo performance, including ready cleavage by endogenous serum proteases.Methodology/Principal FindingsTo explore the potential for peptoid residues to replace well studied CAMP scaffolds we have produced a series of antimicrobial lipopeptoids, with sequences similar to previously reported lipopeptides. The activity of the peptoids was assessed against a panel of clinically relevant and laboratory reference bacteria, and the potential for non-specific binding was determined through hemolytic testing and repeating the antimicrobial testing in the presence of added bovine serum albumin (BSA). The most active peptoids displayed good to moderate activity against most of the Gram positive strains tested and moderate to limited activity against the Gram negatives. Antimicrobial activity was positively correlated with toxicity towards eukaryotic cells, but was almost completely eliminated by adding BSA.Conclusion/SignificanceThe lipopeptoids had similar activities to the previously reported lipopeptides, confirming their potential to act as replacement, proteolytically stable scaffolds for CAMPs.

LE JOURNAL CANADIEN DES SCIENCES NEUROLOGIQUES Suppl. 2-S17 surgeries. Results: 14 surgeries were performed in 11 patients (three patients had bilateral SSCD). Most patients were males (82%). Age range was 32-68 years. Surgeries were done by a team of a neurosur-geon and a neuro-otologist. Localization of SSCD was done using stereotactic guidance. Five layers' reconstruction was performed in all patients. All patients had significant improvement in symptoms without sensorineural hearing loss. None of the patients developed post-operative hematoma, infection, seizures, CSF leakage or facial palsy. LOS was 1-2 days. Conclusions: MCF with multi layers reconstruction should be considered as a safe and effective approach in severely symptomatic patients. We demonstrated that this approach has minimal risks especially in regards to sensorineural hearing loss. Background: Unlike non-Hodgkin's lymphoma, central nervous system involvement with classical Hodgkin's lymphoma is exceedingly rare, thus information regarding treatment and prognostication of the disease is lacking. Methods: This case report was prepared using hospital charts, and PubMed for the literature search. Our case was compared and contrasted against similar cases in the literature. Results: We present the case of a 47 year old female who presented with a left parietal dural-based lesion which proved to be Stage IE primary CNS classical Hodgkin's lymphoma. After surgery and whole brain radiation therapy, the patient has remained in complete remission over nine years. Conclusions: Despite the dearth of information available regarding CNS Hodgkin's lymphoma, our case is consistent with the findings in the literature that long-term survival is possible in patients achieving a complete response to treatment, especially in those patients who present with sole CNS involvement. To our knowledge, this represents the longest reported survival in the literature and contributes to our understanding of prognosis in patients with CNS Hodgkin's lymphoma. Background: Cerebral venous sinus thrombosis (CVST) is a possible complication of closed head trauma with reported devastating outcomes. Its incidence however is unclear but believed to be frequent in patients with skull base fractures. The natural history of this under-recognized entity is not yet described, but a sensitive screening method is required to definitively address this question. Methods: Case report with literature review. Results: We report the case of a patient that sustained a severe head injury as the pedestrian in a motor vehicle accident. The patient required required a craniectomy to evacuate an acute subdural hematoma. Post-operatively, a CT veno-gram was performed and showed patent venous sinuses. A few days later, a double order resulted in a CTV being repeated erroneously but revealed the interval development of significant thrombosis of his left transverse sinus extending to his left internal jugular vein. We report on this patient's outcome and follow-up. Conclusions: Further understanding of...

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