In this work a new approach to address multivariable control structure (MCS) design for medium/large-scale processes is proposed. The classical MCS design methodologies rely on superstructure representations which define sequential and/or bilevel mixed-integer nonlinear programming (MINLP) problems. The main drawbacks of this kind of approach are the complexity of the required solution methods (stochastic/deterministic global search), the computational time, and the optimality of the solution when simplifications are made. Instead, this work shows that, by using the sum of squared deviations (SSD) as well as the net load evaluation (NLE) concepts, the control structure design problem can be formulated as a mixed-integer quadratic programming (MIQP) model with linear constraints, featuring both optimality and improved computational performance due to state-of-the-art solvers. The formulation is implemented in the GAMS environment using CPLEX as the selected solver and two typical case studies are presented to show the benefits of the proposed approach.
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