Background Human papillomavirus (HPV) and Trichomonas vaginalis (TV) infections are the most common sexually transmitted infections (STIs) globally. The latter has contributed to a variety of adverse outcomes for both sexes. Moreover, in Brazil, epidemiological studies on patients with STIs are limited. Therefore, this study aimed to determine the prevalence of TV and its association with HPV in women undergoing cervical cancer screening. Methods Women with a normal cervix were recruited from a community-based cervical cancer screening program. Gynecological examinations were conducted, and questionnaires were provided. Vaginal canal and uterine cervix samples were collected for cytological examinations (reported using the 2001 Bethesda System) and tested for the presence of TV and HPV DNA. Results In total, 562 women who attended public primary healthcare were included in the study. The T. vaginalis was present in 19.0% (107) and HPV DNA was present in 46.8% (263) of women. Among the women of TV 73.8% (79) had a co-infection with HPV (p = 0.001). Conclusions We concluded that a TV infection is associated with an HPV infection of the cervix as well as with the cervical cytological abnormalities. Further studies could reveal the mechanisms by which these two organisms interact at the cellular level, with control for shared behavioral risk factors.

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Objective: to carry out an evaluation of the hygienic-sanitary conditions of food sold in the Central Market in São Luís - MA. Methodology: For the hygienic-sanitary evaluation from the legal point of view of the Central Market, the checklist set out as Annex I in RDC No. 216 of September 15, 2004 from Anvisa / Ministry of Health, which deals with the Technical Regulation of Good Practices for Food Services. The form was filled out according to the apparent analysis of the place, judging the items arranged in it in positive or negative for different subjects such as structure and hygienic habits of the sellers. Results: In the Central Market, it was found that, regarding the physical structure of the site, of the 08 criteria analyzed, 05 were negative, showing the precariousness of the premises' facilities. In the assessment of the hygiene and clothing habits of the handlers, of the 09 items analyzed, only 01 was attended to, while 08 were negative, although 02 of these were marked as positive. Regarding the aspects and quality of the food, of the 12 items analyzed, only 04 were in accordance with the standards, while 08 criteria obtained negative results. Conclusion: This study demonstrated the poor hygiene in the commercialization of food in the Central Market in São Luís - MA, from the premises of the place, quality and aspect of the food, to the hygienic habits and clothing of the handlers.

Objective. To verify the association between HPV infection and the presence of coinfections (Chlamydia trachomatis, Trichomonas vaginalis, and Neisseria gonorrhoeae) in women in the state of Maranhão. Methods. HPV-DNA detection was performed by the nested PCR, using the primers PGMY09/11 and GP + 5/GP + 6. For the identification of sexually transmitted agents, conventional PCR was performed using the following primers: KL1/KL2 (Chlamydia trachomatis), TVA5/TVA6 (Trichomonas vaginalis), and HO1/HO3 (Neisseria gonorrhoeae). DNA-HPV positive samples were subjected to automated sequencing for genotyping. Results. Among the 353 women evaluated, 204 (57.8%) had HPV-DNA, of which 140 (68.6%) exhibited HPV/STIs, while 64 (31.4%) had the only HPV. T. vaginalis infection showed a positive association with HPV ( p = 0.003 ). Women without cervical lesions were predominant (327/92.6%); however, the largest number of lesions was reported in women who had HPV/coinfections (18/8.8%). Multiple regression analysis showed that both HPV only and the concomitant presence of HPV/STI were able to indicate the occurrence of epithelial lesions (R = 0.164; R2 = 0.027). Conclusion. The findings suggest that the presence of T. vaginalis can contribute to HPV infection, and HPV/IST association may influence the development of cervical intraepithelial lesions that are precursors of cervical cancer.

O gênero Jatropha, está inserido na família Euphorbiaceae. Esta família compreende 290 gêneros e aproximadamente 7500 espécies, distribuídas em todo o mundo, principalmente nas regiões tropicais. Esse estudo objetivou realizar a prospecção de patentes das principais aplicações biológicas do gênero Jatropha. Para a realização da pesquisa, utilizaram-se as bases Instituto Nacional de Propriedade Industrial do Brasil (INPI), European Patent Office (Espacenet), United States Patent and Trademark Office (USPTO), World Intellectual Property Organization (WIPO) e os descritores A base da WIPO obteve maior número de patentes (n = 724), predominando a classificação C12N (n = 153). O número de patentes depositadas sobre o gênero de plantas Jatropha pode ser considerado alto quando pesquisado de forma geral (n = 1434), porém, ao se especificar apenas os efeitos farmacológicos do gênero, são encontrados poucos depósitos de patentes (n = 38), o que demonstra a falta de incentivo no registro de patentes direcionadas para essa tecnologia na área farmacológica, apesar de ser um campo de interesse comercial, assim como, um direcionamento das pesquisas científicas no atendimento às reais necessidades da sociedade e do setor econômico.

O câncer do colo do útero (CCU) é considerado um grave problema de saúde pública, apresentando além de alta incidência, uma grande morbimortalidade em todo o mundo. Este trabalho teve como objetivo avaliar o perfil epidemiológico e citopatológico do câncer do colo do útero diagnosticados na cidade de São Luís no período de 2015 a 2020. Foi desenvolvido um estudo epidemiológico de natureza descritiva e com abordagem quantitativa e retrospectiva com dados coletados referentes a cidade de São Luís, Maranhão, Brasil. Estes dados foram coletados a partir do Sistema de Informação do Câncer (SISCAN) e discutidos com base em artigos publicados em periódicos e base de dados on-line.  Foram registrados 302.532 exames realizados no período de estudo. O ano de 2019 apresentou a maior quantidade de exames (25,4%). A faixa etária com maior número de exames compreendia entre 30 a 39 anos, totalizando 25,5%. Quanto à adequabilidade 98,4% das amostras classificaram-se como satisfatórias. O epitélio escamoso foi o mais representado nas amostras citopatológicas (58%). O rastreamento (99,1%) do CCU foi o principal motivo para a realização do exame. Dentre as alterações celulares benignas, a inflamação foi o achado com maior quantidade de registros (77,1%) e as lesões intraepiteliais de baixo grau foram as mais recorrentes (1,12%) entre as anormalidades celulares. Este estudo demonstra a necessidade da realização periódica de exames preventivos para o diagnóstico de CCU, uma vez que este tipo de câncer é passível de prevenção e cura, principalmente quando as lesões são diagnosticadas no estágio inicial.

Introdução: As neoplasias hematológicas são importantes causas de morte na infância e adolescência. Objetivo: Caracterizar o perfil demográfico e clínico de casos notificados de neoplasias hematológicas em crianças e adolescentes em um hospital de referência do município de São Luís, Maranhão, Brasil. Método: Estudo observacional retrospectivo com dados coletados de prontuários médicos de casos de neoplasias hematológicas em pacientes com idade até 19 anos registrados em um hospital público de referência para tratamento oncológico, no período de 2005 a 2015. Foram coletados dados de caracterização geral dos pacientes e dados do seguimento do tratamento. Os testes qui-quadrado e exato de Fisher foram utilizados na análise estatística. O nível de significância adotado foi de 5% (p<0,05). Resultados: Os casos de óbito foram mais elevados nos pacientes diagnosticados com linfoma não Hodgkin. A maioria dos pacientes com leucemia linfoide era do sexo masculino com idade até 5 anos, e a frequência de óbito nos pacientes com leucemia linfoide foi mais baixa nos casos confirmados de leucemia linfoblástica de células precursoras tipo B em comparação a outras categorias. Conclusão: Os achados sugerem que a maioria dos pacientes com até 19 anos diagnosticados com leucemia linfoide era do sexo masculino e com idade até 5 anos.

Background: human papillomavirus is one of the most common sexually transmitted infections in the world, with a higher prevalence among young adults at the onset of sexual activity, Methods: prospective cross-sectional study were performed among 162 women aged between 18 and 73 years. For the DNA/HPV isolation, samples were collected and placed in the HC2 DNA Collection buffer (QIAGEN, CA, USA), and frozen at -20°C until processed. DNA/HPV extraction were performed by using QIAamp DNA Mini and Blood kit (QIAGEN, CA, USA) according to manufacturer instructions. Total DNA was isolated, eluted in 100 mL AE buffer and stored at 80˚C. Extracted DNA was quantified using a NanoVue unit (GE Healthcare Life Sciences, Little Chalfont, UK). Statistical analysis was performed using IBM SPSS® software version 23. Data were initially subjected to descriptive analysis, plus mean and standard deviation. Results: among the participants, 61.7% had DNA / HPV and 66.7% were users of illicit drugs and 59.3% were non-users, making them statistically significant. Among DNA/HPV positive users there was a higher proportion of sexually transmitted infections (STIs) (27.9%) compared to non-users (9.27%) (p> 0.05). Conclusion: the vulnerability of women to STIs and the high influence caused by the socioeconomic context in the course of these infections, the importance of public policies that establish appropriate strategies for their prevention, early diagnosis and treatment is emphasized, so that there is. The Research Ethics Committee of the University Hospital of the Federal University of Maranhão approved the project under the number CAAE 76328917.5.0000.5086, and informed consent was obtained from all subjects.