Docetaxel is significantly superior to MV in terms of response, TTP, and survival. The safety profiles of both therapies are manageable and tolerable. Docetaxel represents a clear treatment option for patients with MBC progressing despite previous anthracycline-containing chemotherapy.
Abstract:Simmering debates leading to polarization are observed in many domains. Although empirical findings show a strong correlation between this phenomenon and modularity of a social network, still little is known about the actual mechanisms driving communities to conflicting opinions. In this paper, we used an agentbased model to check if the polarization may be induced by a competition between two types of social response: conformity and anticonformity. The proposed model builds on the q-voter model (Castellano et al. b) and uses a double-clique topology in order to capture segmentation of a community. Our results indicate that the interplay between intra-clique conformity and inter-clique anticonformity may indeed lead to a bi-polarized state of the entire system. We have found a dynamic phase transition controlled by the fraction L of negative cross-links between cliques. In the regime of small values of L the system is able to reach the total positive consensus. If the values of L are large enough, anticonformity takes over and the system always ends up in a polarized stated. Putting it the other way around, the segmentation of the network is not a su icient condition for the polarization to appear. A suitable level of antagonistic interactions between segments is required to arrive at a polarized steady state within our model.
Monitoring of cardiovascular hemodynamic changes requires a very expensive and highly specialized equipment and skilled medical personnel. Up to the present time, an inexpensive, non-invasive and easy-to-use method which, like Doppler echocardiography, magnetic resonance angiography or radionuclide imaging, would assess hemodynamics of the cardiovascular system was not available. A method known as impedance cardiography (ICG) or thoracic electrical bioimpedance cardiography (TEBC) meets those criteria. It is non-invasive, which is of a particular advantage over the conventional methods that require catheterization. As a result, the patient is not at risk of possible complications and the procedure is less expensive and easier. Impedance cardiography, despite its non-invasive character, has not been so far extensively used for monitoring of hemodynamic parameters in hospitalized patients. Various authors report that attempts have been continued to compare the results from ICG and those obtained by other diagnostic methods. This paper presents the use of impedance cardiography in diagnosis of hypertension, cardiac insufficiency, differentiating the causes of acute dyspnea, as well as in assessing the effects of cardiac rehabilitation in patients with heart failure.
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