The systematic variation within a set of data, as represented by a usual statistical model, may be used to encode the data in a more compact form than would be possible if they were considered to be purely random. The encoded form has two parts. The first states the inferred estimates of the unknown parameters in the model, the second states the data using an optimal code based on the data probability distribution implied by those parameter estimates. Choosing the model and the estimates that give the most compact coding leads to an interesting general inference procedure. In its strict form it has great generality and several nice properties but is computationally infeasible. An approximate form is developed and its relation to other methods is explored.

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Based on these data, pretreatment allergen-specific IgE levels do not provide any better prediction of response to treatment as compared with pretreatment total IgE. At present, the most reliable method of identifying patients who respond to omalizumab treatment remains a physician's assessment.