Sixty-four patients with non metastatic high risk breast cancer were randomized in a double blind trial of adjuvant immunotherapy with sodium dithiocarb (DDC) versus placebo. All patients underwent prior surgery (mammectomy according to Patey) then adjuvant FAC chemotherapy +/- DDC. With a median follow-up of 5 years we observed 6 relapses and 5 deaths in DDC group; 13 relapses and 12 deaths in control group. At 6 years, overall survival is 81% in DDC group versus 55%. Disease free survival (DFS) is 76% in DDC group versus 55%. DDC associated to chemotherapy and locoregional treatment can improve survival and probably DFS in this high risk breast cancer subgroup.

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This paper is a review of the recent technical and clinical advances in the area of breast thermography. Emphasis is placed upon thermal imaging using liquid crystal films, and computer-assisted analysis of breast thermograms. New data are presented concerning the value of thermography for the identification of women at high risk of developing breast cancer, the early detection of mammary carcinomas, and the detection of cancer in fibrocystic breasts.

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