Background
Gastric cancer (GC) is one of the leading causes of morbidity and mortality worldwide. The onset and progression of gastric cancer are attributed to numerous triggers, these triggers may be infection of the gastric epithelium by
Helicobacter pylori
(
H. pylori
), or by Epstein-Barr virus (EBV). Both agents can establish a lifelong persistent infection in the host, leading to chronic inflammation, which also contributes to cancer development. Objective: The objective of this study is to present the status of co-infection with
H. pylori
and EBV and the risk of developing adenocarcinoma at an early age in the population of Grand Casablanca.
Methods
In this study, 100 gastric tissue samples from patients with gastric cancer were examined for detection of
H. pylori
and EBV in tumor tissue using PCR techniques, and the clinical relevance was statistically analyzed.
Results
Results revealed an individual Epstein-Barr virus (EBV) infection observed in (40 %) of gastric carcinoma cases. Furthermore, the frequency of EBV infection was significantly different with intestinal and diffuse gastric cancer types [15 % vs. 85 %; <0.05]. The prevalence of individual
H. pylori
infections was 34 %, while the frequency of co-infection was 16 %. Moreover, no significant association was found between co-infection and sex, tumor grade, stage, and lymph node metastasis, but there was a significant association between co-infection and the age of GC patients.
Conclusion
Thus understanding the status of co-infection could clarify the process of gastric carcinogenesis, and application of this knowledge for clinical purposes could facilitate diagnosis, risk management, and prevention.
Highlights
Polysplenia is a complex polymalformative syndrome that includes a spectrum of visceral and vascular anatomical abnormalities; extremely undiscovered in adulthood.
A rare case of polysplenia syndrome showing an exceptional association between preduodenal portal vein, dorsal pancreas agenesis and polysplenia on gastric adenocarcinoma.
Surgeons must be aware of their possible existence and be able to recognize them to avoid major intraoperative injuries.
Surgeons must have a perfect knowledge of the reference anatomy and the exploration of anatomical variations in imaging before surgical exploration.
PDPV is believed to pose increased risk to gastric cancer patients during gastrectomy and lymph node dissection around the hepatoduodenal ligament.
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