ACPA-containing immune complexes induce TNFα secretion by blood and synovial fluid-derived macrophages from RA patients, fitting with their probable involvement in RA pathophysiology.

No abstract

Vitamin D deficiency does not impair biochemical markers of bone metabolism in patients with multiple myeloma, before or after ASCT.

Recently, Kaiser et al. (1) and Heider et al.(2) demonstrated that Dickkopf-1 (DKK1) was associated with the extent of bone disease in multiple myeloma (MM). It decreases in patients responding to antimyeloma treatment. Dickkopf-1 (DKK1) is one of the inhibitors of Wnt, a central pathway for bone formation (1). It is produced by myeloma cells (3) and is involved in the mechanism of lytic bone lesions in MM (4, 5). To evaluate the prognostic value of serum levels of DKK1 in treatment response and the relapse after autograft stem cell transplantation (ASCT), we analysed serum DKK1 levels before and after ASCT.