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Routine red cell counts and hemoglobin determinations yield information that is valuable but very incomplete. This information concerns only the concentration of the blood. These routine methods do not furnish us absolute values for hemoglobin, for red cells, or for the oxygen-carrying capacity of the blood. With them, an anemia may be more apparent than real, as it may be dependent on or associated with a marked increase in plasma volume, while a polycythemia does not necessarily indicate an absolute increase in red cells, as it may be dependent on a decrease in plasma. In order to obtain absolute values for either red cells or hemoglobin, data relative to plasma volume or total blood volume are essential. were harmless, so far as could be ascertained. Three mg. per kilo was chosen as the most suitable amount for our purposes. Protocols of cats and dogs studied for toxicity appear below. TOXICITY EXPERIMENTS protocols Cat 1.-Weight, 2.4 kg.; given 750 mg. intravenously; killed in three hours. Cat 2.-Weight, 2.75 kg. ; given 700 mg. intravenously ; killed in twenty hours. Cat 3.-Weight, 1.75 kg.; given 6 mg. to kilogram intravenously; no effect; urine free from albumin afterward.

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