IntroductionMoringa oleifera and Camellia sinensis are edible plants widely distributed in parts of South East of Nigeria. Both are used as a beverage and medicinal plant in the treatment of several ailments by alternative medical practitioners. The in vitro-antioxidant properties of both Moringa oleifera and Camelia sinensis leaves were investigated in the current study.. MethodPhytochemical analysis was carried out to evaluate the flavonoids and total phenolic contents of the plants crude extracts. Also, reducing power ability and nitric oxide scavenging activity of the plants were also determined in order to ascertain their antioxidant capacities to eliminate free radicals, and attenuate oxidative stress. ResultsBoth plant samples demonstrated antioxidant properties. The samples were rich in flavonoid (135.14±5.20 and 208.24±14.38), and total phenolics (62.85±1.70 and 91.68±0.22) for both Moringa oleifera and Camelia sinensis respectively. The plant samples also showed nitric oxide scavenging and reducing power ability. Camelia sinensis appears to be a better antioxidant plant. ConclusionMoringa oleifera and Camelia sinensis contains substantial amount of antioxidant substances which could warrant their utilization in alternative medicine. However, further research works are needed to properly ascertain and harness these bioactive agents present in the plants.
Cite this articleAyoola MB, Ejiofor NC, Ezeagu IE, Achukwu P. Organo-Protective Effect of Moringa oleifera (Moringa) and Camellia sinensis (Green Tea) against Histopathological Damage in Monosodium Glutamate-induced Oxidative-Stressed Rats. cc BackgroundMoringa oleifera and Camellia sinensis are widely consumed edible plants in parts of South East, Nigeria. It is used as a beverage and also used in the treatment of several ailments by alternative medical practitioners because of its medicinal properties medicinal plant. The histopathological damage repair properties of Moringa oleifera and Camelia sinensis on the brain, liver and kidney organs were investigated on monosodium glutamate (MSG)-induced oxidative-stressed rats. MethodTwenty male Wister rats were divided into five groups of four rats each. Rats were administered with 0.6 mg/g body weight (b.w) dose of MSG solution for 14 days to induce oxidative stress. Control group was given distilled water. A subsequent treatment with MO, GT and their mixture for a period of 28 days was carried out. One group was left untreated. On day 28 of the treatment regime, animals were sacrificed and necessary organs (brain, liver and kidney) harvested. These organs were processed according to paraffin wax embedding technique, stained with haematoxylin and eosin for light microscopy. ResultsThe plant samples both showed in vivo nitric oxide scavenging properties. The plant samples also presented an increased catalase enzyme activity and the lipid profile analyses showed no significant difference at 95% level of probability. Both plants resulted in reversing the damage that occurred in MSG-induced oxidative stressed rats. This was particularly true for both the kidney and liver. ConclusionThe study provides a pharmacological basis for the traditional use of Camellia sinensis and Moringa oleifera extracts in alleviating common medical conditions.
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