This novel ALS2 splice-site mutation is causing the loss of exon 18 in the transcript which results in a frameshift after exon 17. This frameshift most probably introduces a stop codon seven amino acids further down the new reading frame (p.993fsX7) and is expected to lead to a premature stop in exon 19 thus leading to a truncated protein after translation.
This article asks if and under what conditions ethnic diversity could become a foundation for a prosperous society. Recent studies on ethnic diversity and social cohesion suggest that diversity has a negative effect on social cohesion and therefore is detrimental to the social prosperity of individuals and communities. This paper argues that although such a negative correlation may apply to contexts with well-consolidated ethnic groups, it does not necessarily apply to 'super-diverse' places with multiple small ethnic groups and multiple social, legal, and cultural differences that cut across ethnicity. Drawing on ethnographic material from East London, the authors contend that in super-diverse places ethnic diversity could become a valuable aspect of community life, while inequalities in social, cultural and symbolic capital become central points of social antagonism to the detriment of prosperity.
This article is about the socially divisive consequences of the UK's 2016 referendum on membership in the European Union. Rather than redressing the country's long-standing class divisions, the referendum has exacerbated them by fuelling negative stereotypes and mutual accusations between Leave and Remain supporters. Drawing on psychoanalytic theories of subjectivity, the article argues that support for Leave and Remain is structured by circulations of affect, fantasies of the good life, and psychic investments in different experiences of immigration, nationalism and social and economic inequality.
This article argues for a citizen social science methodology in which residents from the sites of inquiry play a central role in key activities of the research process and beyond: research design and data collection, presentation and publication of findings, and design and implementation of urban interventions that address challenges to quality of life. This is a way of democratising the research process through sustained engagement with communities and an emphasis on co-designing pathways to impact. The article draws on the authors' experience of running a citizen social science project in Beirut, Lebanon, where citizen scientists, university academics, and NGOs have worked collaboratively to understand what prosperity means for local residents, develop context-specific measures of prosperity, and design and implement small-scale interventions for local challenges.
Critiques of racism figure prominently in debates about Brexit’s causes and consequences. But while racism is often theorized in its social and political dimensions, it has received little attention as a concept that has become entangled in a cycle of contestations, denials and affirmations. By looking at racism’s conceptual dimension, with its multiple contested meanings, this article examines the impact that racism-related critiques and counter-critiques of Brexit have had on people’s political subject-positions. Drawing on case studies of both Leavers and Remainers, it is argued that the common binary view of Brexit as either racist or legitimate fails to resonate with the multiple and complex experiences of people on the ground. The article concludes with a call for a renewed conversation about Brexit on the basis of context-specific experiences and pathways to better futures for communities across the country.
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