The pandemic of the coronavirus infection COVID-19, which began at the end of 2019 and caused by the SARS-CoV-2 virus, has led to unprecedented consequences in the world. By the end of May 2021, in the world there were 167 million infected and 3.5 million died directly from infection [1]. SARS-CoV-2 is a beta coronavirus, so it shares many conserved fragments with other known viruses of this type [2]. Since the beginning of the spread of the COVID-19, one of the important issues of research of the SARS-CoV-2 virus has been the search for its conserved RNA motifs and their functional annotation. These motifs are potential targets for the treatment and diagnosis of a disease caused by the virus. This report examines the structural RNA fragments of SARS-CoV-2, similar to the corresponding fragments in other beta coronaviruses [2]. For these RNA motifs the nucleotide variability during the spread of the virus, depending on their secondary structure, was investigated. All the motifs display the similar background variability although contain hypervariable positions.
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