Atopic dermatitis (AD) is a chronic, recurrent, inflammatory, immune-mediated dermatosis. Approximately 10%-20% of children and 1%-3% of adults suffer from this disease in developed countries. [1][2][3] AD generally develops in individuals with a polygenic inherited predisposition under the influence of external and internal triggers and is accompanied by several immunological complications. [4][5][6] Many loci affecting genetic predisposition to AD have been identified. [7][8][9][10][11][12][13] However, it is impossible to explain the predisposition to AD by only considering its genetic component. The mechanisms underlying the interaction between genetic and environmental factors in the development of AD are not yet fully understood. However, alterations in DNA methylation status have been discussed as a possible cause for the manifestation of many dermatoses. [14] The involvement of epigenetic misregulation in disease pathology has been observed in the skin and/or blood of patients with psoriasis, [15] systemic lupus erythematosus [16][17][18] and vitiligo. [19] Studies on DNA methylation in AD are rare. It is known that the DNA methylation profile of T-lymphocytes differs in patients with AD and psoriasis. [20] Some studies have shown significant differences in the DNA methylation status of individual immune
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.