The Open Targets Platform integrates evidence from genetics, genomics, transcriptomics, drugs, animal models and scientific literature to score and rank target-disease associations for drug target identification. The associations are displayed in an intuitive user interface ( https://www.targetvalidation.org ), and are available through a REST-API ( https://api.opentargets.io/v3/platform/docs/swagger-ui ) and a bulk download ( https://www.targetvalidation.org/downloads/data ). In addition to target-disease associations, we also aggregate and display data at the target and disease levels to aid target prioritisation. Since our first publication two years ago, we have made eight releases, added new data sources for target-disease associations, started including causal genetic variants from non genome-wide targeted arrays, added new target and disease annotations, launched new visualisations and improved existing ones and released a new web tool for batch search of up to 200 targets. We have a new URL for the Open Targets Platform REST-API, new REST endpoints and also removed the need for authorisation for API fair use. Here, we present the latest developments of the Open Targets Platform, expanding the evidence and target-disease associations with new and improved data sources, refining data quality, enhancing website usability, and increasing our user base with our training workshops, user support, social media and bioinformatics forum engagement.

We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The platform provides either a target-centric workflow to identify diseases that may be associated with a specific target, or a disease-centric workflow to identify targets that may be associated with a specific disease. Users can easily transition between these target- and disease-centric workflows. The Open Targets Validation Platform is accessible at https://www.targetvalidation.org.

Metadata onlyThis paper describes a novel computer-aided procedure for generating multiple-choice test items from electronic documents. In addition to employing various Natural Language Processing techniques, including shallow parsing, automatic term extraction, sentence transformation and computing of semantic distance, the system makes use of language resources such as corpora and ontologies. It identifies important concepts in the text and generates questions about these concepts as well as multiple-choice distractors, offering the user the option to post-edit the test items by means of a user-friendly interface. In assisting test developers to produce items in a fast and expedient manner without compromising quality, the tool saves both time and production costs