We aimed to identify unique constellations of sensory phenotypes for genetic etiologies associated with diagnoses of autism spectrum disorder (ASD) and intellectual disability (ID). Caregivers reported on sensory behaviors via the Sensory Profile for 290 participants (younger than 25 years of age) with ASD and/or ID diagnoses, of which ~ 70% have a known pathogenic genetic etiology. Caregivers endorsed poor registration (i.e., high sensory threshold, passive behaviors) for all genetic subgroups relative to an “idiopathic" comparison group with an ASD diagnosis and without a known genetic etiology. Genetic profiles indicated prominent sensory seeking in
ADNP
,
CHD8,
and
DYRK1A
, prominent sensory sensitivities in
SCN2A,
and fewer sensation avoidance behaviors in
GRIN2B
(relative to the idiopathic ASD comparison group).
Supplementary Information
The online version contains supplementary material available at 10.1007/s10803-023-05897-9.
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