Largescale movement of diverse groups of people continue to redefine the demographics of an increasing number of societies all around the world. Global migration has an impact on education as the shift in ethnic demographics profiles comes with dramatic demographic shifts in the student population worldwide as well. Situated within these current geosociopolitical realities, in this position paper we argue for the urgency of culturally relevant pedagogies as a response to the challenge of meeting the needs of increasingly diverse and multicultural science classrooms. In doing so, we first provide a definition of culturally relevant pedagogies alongside a historical overview of how the term has been framed and utilized in science education over the past two decades. Following on these theoretical underpinnings, we synthesize the findings of contemporary empirical research studies that are situated both in and out-of-school contexts. In doing so, we aim to respond to the question of what might be the value of adopting CRP in science education? As the synthesis of related literature shows, there exists a strong relation between CRP and multiple kinds of benefits related to students’ engagement in science, both in out-of-school and in school contexts. These benefits include the three tenets of CRP: increasing academic achievement, cultural competence, and sociopolitical consciousness. Other benefits refer to increasing students’ interest in science, motivation and engagement as well as self-identification with science. We end the paper by offering recommendations for future research based on identified gaps in existing knowledge base.