Objective: To correlate Uroflowmetry with Prostate volume and International Prostatic Symptom Score in BPH patients and healthy adults in a subset of Karachi Population. Study Design and Setting: This is a crossectional study carried out at Ziauddin Hospital, Karachi over a period of 6 months. Methodology: In this study 100 Samples were taken through non probability convenience sampling. Inclusion criteria includes 40years and above. Sample initially was taken on the basis of International Prostatic Symptom Score i.e., less than 8 and greater than 8 score. Ultrasonography was performed. 65 Individuals with International Prostatic Symptom Score > 8 and Prostate volume <25 and individuals having symptom index < 8 and Prostate volume > 25ml went for Uroflowmetry. Mean and standard deviation was taken out for quantitative variables. Univariate analysis and Multiple Linear Regression applied to assess relationship between Uroflowmetry with Prostate volume and International Prostatic Symptom Score. Result: Mean age of patients was found to be 58±6 years. Mean International Prostatic Symptom Score was 11±4. Mean Prostate Volume was 28ml±5, mean Qmax was 14ml/s ±4. The correlation between Qmax and International Prostatic symptom score was found to be negative (-0.78) and statistically significant. No correlation was found between Prostate volume and Qmax. Conclusion: Qmax and International Prostatic Symptom Score are reliable tool for assessing Benign Prostatic Hyperplasia patients concluding that as Symptom Score increases Qmax decreases. Qmax showed no correlation with Prostate volume. Prostate volume assessed on Ultrasonography is not an authentic parameter for diagnosing BPH patients
Objective: To examine the protective effect of aqueous neem leaves extract against damage induced by erythromycin on liver enzyme alkaline phosphatase. Study Design: Laboratory-based experimental study. Place and Duration of Study: Anatomy Department, Baqai Medical University, Karachi Pakistan, from Mar to Jun 2018. Methodology: Eighty male albino wistar rats were taken and were divided randomly into 4 groups. Group-A served as a control group with no drug given. Group-B animals received the drug erythromycin 100 mg/kg body weight orally through gastric lavage. Group-C animals received erythromycin 100 mg/kg body weight and neem leaves extract in a dose of 500 mg/kg body weight orally through gastric lavage. Group-D received only neem extract at the dose of 500 mg/kg body weight orally. After 14 days, blood samples were collected via cardiac puncture and sent to laboratory for the investigation of alkaline phosphatase enzyme. Results: The alkaline phosphatase enzyme levels of group-B (Erythromycin treated group) were found to be 176.98 ± 10.53 IU/L. When treated with aqueous neem leaves extract the alkaline phosphatase levels decreased to 150.10 ± 2.28 IU/L seen in group-C. The comparisons of group-B and group-C showed statistically significant (p<0.01), showing protective effect of aqueous neem leaves on hepatocytes. Conclusion: Aqueous neem extract showed protective effect on erythromycin induced hepatic damage.
Objective: To determine the protective effect of aqueous Neem leaf extract-induced hepatotoxicity by Erythromycin.Study Design: Laboratory-based Experimental study.Place and Duration of Study: The study was conducted at the Department of Anatomy and Animal House of Baqai Medical University (BMU) Karachi, Pakistan from January 2019 to March 2019.Materials and Methods: A total of 80 albino Wistar male rats were randomly divided into 4 groups. Control group, marked as Group A with no interventions. Only Erythromycin was administered to the rats in group B. Erythromycin and an aqueous extract of neemleaves were administered to group C rats. Group D only received an extract of aqueous neemleaves. Animals' body weight was noted both before and after experiments. Liver weight was also measured after 14 days when the animals were sacrificed.Results: Histopathological changes in group B include loss of architecture, portal vein observed with congestion, and hemorrhages. In Group C, histopathological changes showed hepatocytes with slightly disturbed and mild congestion with decreased sinusoidal spaces; however, Group A andGroup D observed normal hepatocyte architecture. Conclusion: According to the current study, Erythromycin-induced oxidative stress and hepatocyte damage weremarkedly reduced by aqueous neem leaf extract, which is a powerful antioxidant.
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