Because it promotes the lightening of pigment spots, tyrosinase inhibition is one of the mechanisms of depigmenting cosmetic products. Considering the adverse effects produced by synthetic depigmenting actives, the search for new therapeutic options is desirable, and plant extracts are possible candidates for hyperpigmentation treatment. Glycolic extracts of Cecropia pachystachya Trécul are, therefore, the focus of this study. Its chemical characterization, antioxidant activity, tyrosinase inhibition, and cell viability were evaluated. Glycolic extracts were obtained by macerating the leaves of C. pachystachya in grain alcohol and glycerin or propylene glycol. Both had a similar chemical constitution, the glycerin being more efficient in concentrating phenolic compounds and flavonoids. Analyses by UHPLC-MS detected quinic acid, chlorogenic acid isomers, proanthocyanidin dimers type B and C, catechin/epicatechin, orientin/isoorientin, isoorientin 2"-O-xyloside, vitexin/isovitexin, and rutin. 5-O-caffeoylquinic acid was then quantified was then quantified, with predominance in the extract produced with propylene glycol. These extracts showed a high antioxidant capacity by the method of DPPH, β-carotene, and nitric oxide. As for depigmenting activity, both extracts were able to inhibit tyrosinase. Cell viability assay also revealed that the extracts could safely be used in concentrations of ≤ 125 µg/mL. Thus, this study demonstrated for the first time that the glycolic extracts of C. pachystachya have promising chemical and biological characteristics for the development of a multifunctional cosmetic with antioxidant and tyrosinase-inhibition activities.
As leishmanioses são infecções causadas por protozoários do gênero Leishmania, responsáveis por altas taxas de morbidade e mortalidade em todo mundo. O tratamento está restrito a um número limitado de fármacos com alta toxicidade, variabilidade na eficácia e alto custo. Neste trabalho foram sintetizados quatro bioisósteros do resveratrol que foram avaliados em formas promastigotas de Leishmania amazonensis e L. braziliensis associadas à manifestação tegumentar da doença, além da citotoxicidade em macrófagos murinos. Dois dos compostos, 1a e 1b exibiram promissores resultados, com CI50 variando de 3,0 a 16,44 µM, e não apresentaram toxicidade em macrófagos peritoneais. O composto 1b exibiu o maior índice de seletividade (> 25) para ambas as espécies. Esses resultados indicam o potencial desta classe de compostos para o desenvolvimento de novos agentes antileishmaniais e estimulam a realização de estudos em amastigotas intracelulares e a avaliação do seu mecanismo de ação.
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