This study aims to describe sample size determination procedure in survival analysis using a real-world example. In this method simulation is used for sample size and precision calculations with censored data that concentrates on various sample sizes involved in carrying out the estimates and precision calculation. The Kaplan-Meier (K-M) estimator is chosen as a point estimator, and the precision measurement focuses on the mean square error, standard error, and confidence limits. Information obtained on the recovery time, in days, of patients from the population are compared with results taken from the sample group. Results showed a cutoff point of sample of size 675 on the basis of mean square error, standard error and confidence limit.
This research was carried out to quantify the duration from symptom onset to recovery/death (SOR/SOD) during the first four waves and the Alpha/Delta period of the epidemic in Khyber Pakhtunkhwa, Pakistan, and identify the associated factors. A total of 173,894 COVID-19 cases were admitted between 16 March 2020 and 30 November 2021, including 458 intensive care unit (ICU) cases. The results showed that the case fatality rate (CFR) increased with age, and females had a higher CFR. The median SOR of ICU cases was longer than that of non-ICU cases (27.6 vs. 17.0 days), while the median SOD was much shorter (6.9 vs. 8.4 days). The SOR and SOD in the Delta period were slightly shortened than the Alpha period. Age, cardiovascular diseases, chronic lung disease, diabetes, fever, breathing issues, and ICU admission were risk factors that were significantly associated with SOD (p < 0.001). A control measure, in-home quarantine, was found to be significantly associated with longer SOD (odds ratio = 9.49, p < 0.001). Infected vaccinated individuals had longer SOD than unvaccinated individuals, especially for cases that had received two vaccine doses (p < 0.001). Finally, an advice on getting full-dose vaccination is given specifically to individuals aged 20–59 years.
The present study was aimed to improve the general public understanding of COVID-19 pandemic, current study aims to estimate the recovery time of patients infected from COVID-19. Data for this retrospective study was taken from the Saidu group of teaching hospitals district Swat, Khyber Pakhtunkhwa, Pakistan. The study period was form March 24, 2020, to August 25, 2020. A total of 372 COVID-19 positive cases from March 2020 to August 2020 were included in the study. The entry point of each patient was the date of admission in the hospital and the event of interest was the recovery of a patient from COVID-19. Variable of interest were date of admission, date of discharge, age and gender for all patients. All 372 patients were COVID-19 positive recorded between the first positive to the first negative SARS-CoV-2 PCR test results. The Kaplan Meier estimator was used to obtain the recovery time of patients in days from COVID-19 diagnosis. Present study estimated average time of recovery from COVID-19 in district Swat which was 8 days with 0.95% C.I. (7-9) days. The difference between recovery time for males and females was not significant but the difference between recovery time for age groups was significant using the log-rank test.
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