P16(INK4A) expression and HGAOT are independent prognostic factors for OS of patients with HNSCC, whereas p16(INK4A) expression is particularly important for patients without HGAOT.
A high CXCR4 expression could be regarded as a negative prognostic factor in head and neck cancer because it may foster metastatic spread. This may recommend CXCR4 as therapeutic target for combating head and neck cancer metastasis.
Completing a thesis is a scientific challenge. Without the generous guidance and the help of several individuals who in one way or another contributed and extended their valuable assistance in the preparation and completion of this study, it cannot be successfully done. I am deeply grateful to Prof. Dr. Peter Burfeind, for his useful suggestion, aspiring guidance, encouragement, criticism and trust. I also express my warm thanks to Prof. Dr. Holger Reichardt, for his scientific discussions and suggestions. I gratefully acknowledged PD. Dr. med. Hendrik Wolff, for his personal attention, academic and financial support. For giving me the opportunity to perform such an important and also exciting research in his research group. He positively encouraged and constructively prodded me along, and for this, I am very thankful. Special thanks go to laboratory leader Ms. Margret Rave-Fränk, for her constructive advices, valuable suggestion and patient correction of my thesis. Her expertise and advice were very beneficial for the progress of my project. Thanks are also addressed to Dr. med. Julia Kitz and Dr. Li Li for collaborating with me and giving me the opportunity to do some of my experimental work in their laboratory, in the Department of Pathology. Dr. Li, I really appreciate the scientific discussion we had. Thank you to Dr. Kitz for our social and research conservation. This research project would not have been possible without the support of members of the Radiotherapy and Radiation Oncology laboratories, for technical help and for sharing their time with me, and also for the friendship and constant support: Juliane Kasten-Krapp, Alexandra Bitter and Sandra Hoffmeister. In addition, the laboratory staffs of the Department of Pathology for the warm welcome help and support: Judith Wolf-Salgo and Anke Klages.A special thanks to my parents, my sister and friends for supporting me through this endeavour; my father, for his support and interest in my work through all the time, my dear mother, no words will describe her importance in my life, who continuously inspired me and Acknowledgement vi encourage me to go beyond my limit, and my sister for her endless love and persistent confidence in me.Last but not least, I would like to thank my husband, for his faithful love, kindness, constant patience and support he has shown during the past three years, which has taken me to finalize this thesis. V Volt VEGF Vascular endothelial growth factor vs. versus WB Western blot WHO The World Health Organization µ Micro = 10 -6 1.1.4 Survival of HNSCC patients and tumour recurrence Despite improvements in surgical techniques, chemotherapy (CT) and radiotherapy (RT), the five-year survival rate for patients with HNSCC has remained relatively stable at less than 50% and has not changed since the 1960's (Forastiere et al. 2001, Bose et al. 2013). LowThe management of patients with HNSCC is currently a significant oncological challenge.The overall aim is to achieve increasingly higher survival rates. The consequences of treatment failu...
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