BACKGROUND: Usually, surgical intervention is needed to eradicate the fungal microorganism that cause fungal corneal ulcers. However, since surgical intervention is invasive, the latest technology uses cryotherapy in treating it. Cryotherapy plays a vital role in the wound healing process. We aimed to evaluate is to study the decreased expression of matrix metalloproteinase 9 (MMP-9) and transforming growth factor β1 (TGF-β1) in fungal corneal ulcers after the administration of cryotherapy.METHODS: Aspergillus flavus fungus was injected to the intrastromal corneas of all Sprague Dawley rats. The rats were divided into four groups, the first group was not given any therapy, the second group was given topical natamycin therapy, the third group was given cryotherapy, and the fourth group was given a combination between cryotherapy and topical natamycin therapy. Therapy was given after five days of follow up on the formation of a corneal ulcer. After four days of therapy, the eyes were enucleated to determine MMP-9 and TGF-β1 expression.RESULTS: The result in the third group showed lower MMP-9 expression (20.0±10.0% cells per field of view) compared to the second group (40.0±20.0% cells per field of view) and the fourth group (30.0±25.0% cells per field of view), but had the same MMP-9 expression value as the first group. There was no significant difference in MMP-9 expression between the four groups (p=0.356). The third group reduced more TGF-β1 expression (10.0±12.50% cells per field of view) compared to the fourth group (30±27.5% cells per field of view) and the first group (30±32.5% cells per field of view). There was also no significant difference in TGF-β1 between the four groups (p=0.315).CONCLUSION: There is no significant difference in the expression of TGF-β1 and MMP-9 after the cryotherapy treatment.KEYWORDS: corneal ulcer, cryotherapy, MMP-9, TGF-β1
Aims and Objectives:The aim of the study was to analyse risk factors, surgical outcomes, ovarian salvage rate, and mass histopathology. Objectives of the study was to draw the attention to the clinical, sonographic, surgical, and pathological signs and symptoms and characteristics of histologically proven ovarian torsion instances. Method: This study took place at the Department of Obstetrics and Gynecology, Kamineni Institute of Medical Sciences in Narketpally from July 2021 to July 2022. Retrospective analyses of demographic, clinicopathological, surgical, and sonographic data were performed on 16 patients with ovarian torsion who underwent surgery. All instances of sudden, severe, acute abdomen pain were looked at clinically and radiologically. After receiving the findings, emergency surgery was performed. Result: 31 was the mean age. Pelvis or abdominal pain was the major complaint in our investigation. A pre-existing ovarian mass is a significant risk factor for torsion. 60% had emergent exploratory laparotomy, 40% laparoscopic operation. 40% had cystectomy, 60% oophorectomy. Most prevalent was serous cystadenoma. Conclusion:Study shows that ovarian torsion causes abdominal or pelvic pain. Pre-existing ovarian mass is a risk factor for torsion. Ovarian torsion can develop at any age. Ultrasound imaging is most frequently used to assess torsion but confirmative diagnosis by intraoperative finding. To preserve ovarian tissue, act quickly.
The aim of this case report was to present further study about diagnosis and management of bilateral compressive optic neuropathy induced by schwannoma. This case report will discuss about the definition, classification, etiology, clinical diagnosis and treatment for compressive optic neuropathy. A case report. 43 years-old woman complained about blurred vision since 2 years ago. She also complained about pain on her right head while she was walking. There was no history of tinnitus or hearing loss. She had a history of contraception pill uses and progesterone injection every 3 months for 5 years alternately. She also suffered from schwannoma in cerebello pontine angle based on MRI and histopathology examination. From physical examination, best corrected visual acuity on right eye was 5/6 PHNI and on left eye was 5/8 PHNI. Ishihara test showed decreased colour vision. There was also ataxic gait. From anterior segment examination, there were decreased light reflex and RAPD. From posterior segment examination, there were papilloedema and elevation on both eyes proved by OCT and fundal imaging. Neuroprotector therapy and surgery show a good result. Ishihara test are improving, light reflex are increasing and there are no RAPD anymore. From posterior segment, papilloedema are slowly diminished. The patient presents a case of bilateral compressive optic neuropathy induced by schwannoma. Neuroprotector and surgery show a good result.
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