Raspberry ketone (RK) is an aromatic phenolic compound naturally occurring in red raspberries, kiwifruit, peaches, and apples and reported for its potential therapeutic and nutraceutical properties. Studies in cells and rodents have suggested an important role for RK in hepatic/cardio/gastric protection and as an anti-hyperlipidemic, anti-obesity, depigmentation, and sexual maturation agent. Raspberry ketone-mediated activation of peroxisome proliferator-activated receptor-α (PPAR-α) stands out as one of its main modes of action. Although rodent studies have demonstrated the efficacious effects of RK, its mechanism remains largely unknown. In spite of a lack of reliable human research, RK is marketed as a health supplement, at very high doses. In this review, we provide a compilation of scientific research that has been conducted so far, assessing the therapeutic properties of RK in several disease conditions as well as inspiring future research before RK can be considered safe and efficacious with limited side effects as an alternative to modern medicines in the treatment of major lifestyle-based diseases.
Methotrexate is commonly used as anticancer and anti-inflammatory agent to cure various types of cancerous and auto-immune disorders. An optimum dose of MXT is proven to inhibit the di-hydro-folate-reductase that obstruct the purine multiplication. The nanotechnology-based carriers have outranged in since decade and fabricated as multifunctional complexes to cater medicinal agents for biomedical and pharmaceutical applications. The present review aims on upbringing the understanding the various formulation development of MXT-loaded nanocarriers that have been reported with significance in the treatment of cancers. Also, in this paper, we have comprehensively listed various marketed MXT nanoformulation available in the market with a great safety, efficacy and been promising with great results in patients across the globe.
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