The review addresses the currently used materials for spinal stabilization surgery by spinal fusion. Among them: autografts; allo-and xenografts; materials of synthetic and biological origin; growth factors; multipotent mesenchymal stromal cells; grafts made by 3D modeling. We discuss advantages and disadvantages of these materials as reported in the literature; with this analysis, we hope to stimulate further research into the graft biocompatibility and biointegration, especially into the issue of reparative regeneration and graft transformation into the bone tissue.

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92 children, age 8-17 years, with duodenum ulcer were under observation. The peculiarities of EGF level changes in human biological mediums, depending on phase of the disease. The highest EGF level was detected with acute peptic ulcer in the presence of ulcerous defects. EGF level increasing was marked out in the remission phases ulcerous defects healing, and it didn`t reach normal values in gastric juice. EGF content changes in biological mediums were revealed with different variants of duodenum ulcer clinical course in children. The lowest EGF level was marked out in blood, saliva and gastric juice with unfavorable course of the disease (frequent relapses, cicatricial-ulcerous strains formation), which can serve as a prognostic factor.

Objective: To demonstrate the appendicitis-like onset of Crohn’s disease and the detection of granulomas as findings. Materials and Methods: the medical history of a girl with an appedicite-like onset of Crohn’s disease was analyzed. A complete clinical and laboratory, instrumental examination, histological, histomorphometric analysis of the surgical material and biopsy specimens of the mucous membrane of the colon and ileum were carried out. Results: morphological markers of Crohn’s disease were revealed in a girl against the background of complete health with appendicitis-like onset of Crohn’s disease. Conclusion: Crohn’s disease can be disguised as a variety of diseases. It is very important to have the attitude of surgeons to exclude this disease, conduct an intestinal revision and a complete morphological examination of the operating material in case of suspicion.

The aim of the study was to determine the immunohistochemical features of the lymphoid tissue of the mucous membrane (MM) of the colon in children with different course of Crohn’s disease. Methods: the results of IHC and morphometric analyzes of colonic colony of children with Crohn’s disease of uncomplicated and complicated course are presented. Results: An important role of the ratio and distribution of subpopulations of T-lymphocytes of CO and lymphoid clusters in children with Crohn’s disease is shown, depending on the phenotypic variant of the course of the disease. In children with a favorable prognosis of Crohn’s disease, the immunoregulatory index (IRI) was close to normal with a predominance of the CD4 + T-lymphocyte population against the background of a moderately increased number of CD8 + cells and B-lymphocytes. IRI of children of the II group was significantly increased due to a sharp increase in CD4 +, CD8 + T-lymphocytes and CD19 + B-lymphocyte link. Conclusion: A high level of IRI with a pronounced disproportion of intrapopulation T-lymphocytes is combined with an unfavorable course of the disease. For children with uncomplicated course of the disease, a minimal mismatch in the intrapopulation T-lymphocyte system is characteristic against the background of increased IRI.